Jens Lykke-Andersen
Associate Professor
Section of Molecular Biology, UCSD

e-mail: jlykkeandersen@ucsd.edu

Lab Homepage: Lykke-Andersen Lab

  

Dr. Lykke-Andersen joined the faculty at U.C. San Diego effective July 1, 2009.

Rebbapragada, I. and Lykke-Andersen, J. Execution of Nonsense-Mediated mRNA Decay: What Defines a Substrate? Curr. Opin. Cell Biol. 21: 394-402 (2009) (Review).

Singh, G., Rebbapragada, I., and Lykke-Andersen, J. A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay. PLoS Biology 6(4): 860-871 (2008).

Franks, T. and Lykke-Andersen, J. The control of mRNA decapping and processing body formation. Molecular Cell. 32: 605-615 (2008) (Review).

Singh, G., Jakobs, S., Kleedehn, J., and Lykke-Andersen, J. Communication with the exon-junction complex and activation of nonsense-mediated decay by human Upf proteins occur in the cytoplasm. Molecular Cell. 27: 780-792 (2007).

Franks, T. and Lykke-Andersen, J. TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements. Genes Dev. 21: 719-735 (2007).

Wagner, E., Clement, S.L. and Lykke-Andersen, J. An unconventional human Ccr4-Caf1 deadenylase complex in nuclear cajal bodies. Mol. Cell. Biol. 27: 1686-1695 (2007).

Fenger-Grøn, M., Fillman, C., Norrild, B. and Lykke-Andersen, J. Multiple human processing body factors and the ARE-binding protein TTP activate decapping. Molecular Cell 20: 905-915 (2005).

Lykke-Andersen, J. and Wagner, E. Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1. Genes Dev. 19: 351-361 (2005).

     Jens Lykke-Andersen received his Ph.D. from University of Copenhagen, Denmark in 1997. He was a postdoctoral fellow at Yale University Medical School before joining the faculty of MCD Biology at University of Colorado Boulder in 2001. He was named a Pew Scholar in 2003. He joined the Division of Biological Sciences at UCSD in 2009.