Problem Sets
PROBLEM SET 1
The following problem set and reading assignment covers the first week of lectures. This problem set should be discussed in recitation section during the second week of classes. Some problems on tests will be identical to, or quite similar to, the problem set questions, so you should be certain that you have learned enough from lecture and from reading the text to be able to solve such problems on the exam.
REQUIRED TEXT: A studentís companion to Stryerís Biochemistry, by Gumport et al.
READING: Stryer chapter 2.
PROBLEMS:
Stryer pg 44 problems 1a, 2-4, and 6-8.
Gumport pgs 15-20 pjroblems 1-19, 22, 23, and 25-29.
Gumport pgs 22-24 problems 2-10, 16, 18, and 19.
The following problem set will be covered during recitation section in the third week of classes. In working these problems, you should treat the questions as though they were an "open book" exam, and try to see if you can come up with the correct answer by reviewing the appropriate section of the text. After you have done this, you can then check your answers against the answers in Gumport to see if you are right. This approach will give you a bit more practice in thinking through problems than just reading the problem and then the answer without trying to solve the problem on your own.
On January 22 we will hand out a fairly detailed list of the specific facts/concepts which you will need to know for the first exam on January 29. If you want to get a head start, you may want to learn the structures of the 20 common amino acids. In the first exam you will be given the name of a tripeptide in either three letter or one letter abbreviation form (please note that the correct one letter code for tyrosine is "Y" and not the "T" given in the lecture handout), and you will be asked to draw the correct ionic structure at a particular pH value (you will of course be given a table will the pKa values for the N and C termini and for the side chains).
READING: Stryer chapter 7.
PROBLEMS:
Stryer pg. 179 problems 5, 6, 7, 9, 13, and 14.
Gumport pg. 123 problems 1, 2, 4, 5, 6, 9, and 11.
Gumport pg. 116 problems 1-9, 11-14, 16-20, and 23.
The following problem set will be covered during recitation section in the fourth week of classes. In working these problems, you should treat the questions as though they were an "open book" exam, and try to see if you can come up with the correct answer by reviewing the appropriate section of the text. After you have done this, you can then check your answers against the answers in Gumport to see if you are right. This approach will give you a bit more practice in thinking through problems than just reading the problem and then the answer without trying to solve the problem on your own.
READING: Stryer chapter 8.
PROBLEMS:
Stryer pgs. 205-206 problems 2-5 and 9.
Gumport pgs. 144-147 problems 6-11 and 16. (Also solve problems 12-14
if you feel that you need additional practice with data
analysis.)
Gumport pgs. 135-140 problems 1, 10-14, 16, 17, 19-23, 26 and
27.
The following problem set will be covered during recitation section in the fifth week of classes. In working these problems, you should treat the questions as though they were an "open book" exam, and try to see if you can come up with the correct answer by reviewing the appropriate section of the text. After you have done this, you can then check your answers against the answers in Gumport to see if you are right. This approach will give you a bit more practice in thinking through problems than just reading the problem and then the answer without trying to solve the problem on your own.
READING: Stryer chapter 9 pgs 218-230 and chapter 10 pgs 247-252.
PROBLEMS: Stryer pg. 236 problems 9, 10,
14
Gumport pg. 166 problems 9-13
Gumport pg. 162 problems 14-20 and 22
Gumport pg. 185 problems 5-7
Gumport pg. 179 problems 14-19
The following problem set will be covered during recitation section in the sixth week of classes. In working these problems, you should treat the questions as though they were an "open book" exam, and try to see if you can come up with the correct answer by reviewing the appropriate section of the text. After you have done this, you can then check your answers against the answers in Gumport to see if you are right. This approach will give you a bit more practice in thinking through problems than just reading the problem and then the answer without trying to solve the problem on your own.
READING: Stryer chapter 10 pgs 237-244 and pgs 247-260.
PROBLEMS: Stryer pg. 261-2 problems
1,3,4, 6-10
Gumport pg. 185-6 problems 1,2, 8-15
Gumport pg. 179-82 problems 1-3, 5-7, 20-29.
The following problem set will be covered during recitation section in the sixth week of classes. In working these problems, you should treat the questions as though they were an "open book" exam, and try to see if you can come up with the correct answer by reviewing the appropriate section of the text. After you have done this, you can then check your answers against the answers in Gumport to see if you are right. This approach will give you a bit more practice in thinking through problems than just reading the problem and then the answer without trying to solve the problem on your own.
READING: Stryer chapter 11.
PROBLEMS: Stryer pg. 290 problems
4,5
Gumport pg. 202-205 problems 1,3 - 13
Gumport pg. 193-199 problems 1-5, 7-12, 15-24, 27.
The following problem set will be covered during recitation section in the seventh week of classes. In working these problems, you should treat the questions as though they were an "open book" exam, and try to see if you can come up with the correct answer by reviewing the appropriate section of the text. After you have done this, you can then check your answers against the answers in Gumport to see if you are right. This approach will give you a bit more practice in thinking through problems than just reading the problem and then the answer without trying to solve the problem on your own.
READING: Stryer chapter 12.
PROBLEMS: Stryer pg. 324 problems
1,2,3
Gumport pg. 213-219 problems 1-9, 20-26, 28
Gumport pg. 222-224 problems 2,3, and 5-9.
And the problem below
1. You have isolated a new strain of bacteria and would like to know whether leucine and ethylene glycol enter the cells by mediated diffusion or only by a nonmediated route. To do this you measure the initial rates of uptake of these molecules as a function of external concentration and obtain the data below. Which compound(s) enter by the mediated route? What criteria did you use for this decision?
|
COMPOUND |
CONCENTRATION |
INITIAL UPTAKE RATE (arbitrary units) |
|
Leucine |
1uM |
110 |
|
|
2uM |
220 |
|
|
5uM |
480 |
|
|
10uM |
830 |
|
|
30uM |
1700 |
|
|
100uM |
2600 |
|
|
0.5mM |
3100 |
|
|
1mM |
3200 |
|
Ethylene Glycol |
1mM |
1 |
|
|
5mM |
5 |
|
|
10mM |
10 |
|
|
50mM |
50 |
|
|
0.1 M |
100 |
|
|
0.5M |
500 |
|
|
1M |
1000 |
The following problem set will be covered during recitation section in the ninth week of classes. In working these problems, you should treat the questions as though they were an "open book" exam, and try to see if you can come up with the correct answer by reviewing the appropriate section of the text. After you have done this, you can then check your answers against the answers in Gumport to see if you are right. This approach will give you a bit more practice in thinking through problems than just reading the problem and then the answer without trying to solve the problem on your own.
READING: Stryer chapter 14 and chapter 3 pgs 60-63.
PROBLEMS: Stryer pg. 389-390 problems 1-7
Gumport pg. 271-272 problems 1, 5-10, and 12-14.
Gumport pg. 262-268 problems 1-15 and 20.
Gumport pg. 43 problem 6.
Gumport pg. 37-38 problems 20-22.
The following problem set will be covered during recitation section in the tenth week of classes. This is the last problem set and the last reading assignment for BIBC 100.
READING: Stryer chapter 13, pages 341 - 351 ( except for the section on cyclic AMP) and chapter 16.
PROBLEMS: Stryer pg. 360 problem 8 and
pg. 440 problems 1 - 4.
Gumport pg. 252 problems 9 and 14 (except for problem 14b).
Gumport pg. 238 - 245 problems 1 and 26 - 35.
Gumport pg. 303-305 problems 1,4-7, and 9.
Gumport pg. 297-301 problems 1-3,5,7,10-14, 16-19, and
21-23.
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