2.3.8 -- PROGRESSIVE (similarity) ALIGNMENT -- Blosum62 Sequences are entered in the following order: 1)4F2M 4F2MMU 2)LATR LAT1RNO 3)E16H E16HSA 4)ASUR ASUR4XLA 5)HLT2 HLAT2 6)MLT2 MLAT2 7)LATM LAT1MMU 8)HSA2 ORF2HSA 9)HSA1 ORF1HSA 10)MMU1 ORF1MMU 11)HAT1 HB0AT 12)MAT1 MB0AT 13)E16C E16CEL 14)CEL2 ORF2CEL 15)CEL1 ORF1CEL 16)SMA1 ORF1SMA 17)HLT3 HLAT3 18)CEL3 ORF3CEL 19)CEL4 ORF4CEL 20)CEL5 ORF5CEL 21)CEL6 ORF6CEL 22)YKBA YKBABSU 23)MUP1 MUP1SCE 24)YHD6 YHD6SCE ---- Alignment ---- *** (gap penalty = 6) *** 4F2M M A V A G A K R R A V A T P A T A A A E E E R Q A R E K M L E A R LATR M A V A G A K R R A V A A P A T T A A E E E R Q A R E K M L E A R E16H M A G A G P K R R A L A A P A A E E K E E A R E K M L A A K ASUR M A A D S V K R R Q S G A S K T E E E D R Q A A E K M L H Q MLT2 M E K G A R Q R N N T A K N H P G S D T S P E A E A S HLT2 M E E G A R H R N N T E K K H P G G G E S D A S P E HSA2 M V D S T E Y E V A S Q P E V E T S P LATM M V N S T K Y E V A A Q H E A D D G S A HSA1 M E A R E P G R P T P T Y H L V P N T S Q S Q V E E MMU1 M V R K P V V A T I S K G G Y L Q G N M S G R L P S MAT1 M E E T S L R R R R E D E K S T H S T E L K T HAT1 M G D T G L R K R R E D E K S I Q S Q E P E16C M T A E K E P L K S R E G D E A P Q N CEL2 M G K Q E Q S E P L N Q E P S N E H H D E E CEL1 M N E K E E E V S L HLT3 SMA1 M G K S K K E N K D S N A T CEL4 M G S I E G V P T I G D I A A S R H Q M G L W L L I C CEL5 M P D D S R S Q CEL6 M T E S S S E I P CEL3 M Y A R T I F L N C L F P P V V L S E P K I I P E YKBA M H T MUP1 M S E G R T F L S Q L N V F N K E N Y Q F S S S T T K K E V S N S T V YHD6 M E P L L F N S G K A N P S Q D V F I D V E V G D I T T K Y G S 4F2M R G D G A D P E G E G V T L Q R N I T L LATR R G D G A D P E G E G V T L Q R N I T L E16H S A D G S A P A G E G E G V T L Q R N I T L ASUR N G N A E P K S G D G G A V E L Q R T I T L MLT2 S G G G G V A L K K E I G L HLT2 A G S G G G G V A L K K E I G L HSA2 L G D G A S P G P E Q V K L K K E I S L LATM L G D G A S P V A E Q V K L K K E I S L HSA1 D V S S P P Q R S S E T M Q L K K E I S L MMU1 M G D Q E P P G Q E K V V L K K K I T L MAT1 T S L Q K E V G L HAT1 K T T S L Q K E L G L E16C E T E G K G K G L E K S L T L CEL2 V G D K G L E K T M T L CEL1 N Q I K L K P R I S L HLT3 SMA1 E S V A L K K E V S V CEL4 V E L N V E Q I D I Q A CEL5 K M G L CEL6 Q K H T I G L CEL3 N T Q I M D E S H K M G F YKBA E D N G L K K E I G L MUP1 D A D N G A S D F E A G Q Q F A T E L D Q G E K Q L G I YHD6 T N T G S F S S M D T V E A Q A I K A E T A R F M E V P Q G R H L G V 4F2M L N G V A I I V G T I I G S G I F V T P T G V L K E A G S P G L S L LATR I N G V A I I V G T I I G S G I F V T P T G V L K E A G S P G L S L E16H L N G V A I I V G T I I G S G I F V T P T G V L K E A G S P G L A L ASUR V N G V A I I V G T I I G S G I F V T P T G V L R E A G S P G L S L MLT2 V S A C G I I V G N I I G S G I F V S P K G V L E N A G S V G L A L HLT2 V S A C G I I V G N I I G S G I F V S P K G V L E N A G S V G L A L HSA2 L N G V C L I V G N M I G S G I F V S P K G V L I Y S A S F G L S L LATM L N G V C L I V G N M I G S G I F V S P K G V L M Y S A S F G L S L HSA1 L N G V S L V V G N M I G S G I F V S P K G V L V H T A S Y G M S L MMU1 L R G V S I I I G T V I G S G I F I S P K G I L Q N T G S V G M S L MAT1 L S G I C I I V G T I I G S G I F I S P K S V L A N T E S V G P C L HAT1 I S G I S I I V G T I I G S G I F V S P K S V L S N T E A V G P C L E16C F N G V S M I V G C I I G S G I F V S P T G V Q E Q A G S V G L S L CEL2 F N G V S I I V G C I I G S G I F I S P T G I Q A Q A G S V G L S L CEL1 F N G C T I I I G V I I G S G I F V S P K G V L L E A G S A G M S L HLT3 SMA1 L Q G V S I V V G V I I G S G I F V S P V G V L K H T K S V G L S F CEL4 F S M Y M R F S A N I I G A G I F I T P G P I L Q Y T F S N G L A L CEL5 L G A I S Y I V G N I V G S G I F I T P T S I I E N V N S CEL6 I T A I S Y T V G D I V G S G I F I S P T S I L N H A G S V G L S L CEL3 L G A T S Y V I G N I I G S G I F I T P A S I L R N V D S I G L S L YKBA L F A L T L V I G T I I G S G V F M K P G A V L A Y S G D S K M A L MUP1 L S C I G L I C N R M L G T G V F A V S S T I Y T L C G S V G L A L YHD6 F S T V V L F V S R I M G S G I F A V P S V I L L N T G G N K L I Y F 4F2M V V W A V C G V F S I V G A L C Y A E L G T T I S K S G G D Y A Y M LATR V V W A V C G V F S I V G A L C Y A E L G T T I S K S G G D Y A Y M E16H V V W A A C G V F S I V G A L C Y A E L G T T I S K S G G D Y A Y M ASUR L V W A V C G L F S I V G A L C Y A E L G T T I S K S G G D Y A Y V MLT2 I V W I V T G I I T A V G A L C Y A E L G V T I P K S G G D Y S Y V HLT2 I V W I V T G F I T V V G A L C Y A E L G V T I P K S G G D Y S Y V HSA2 V I W A V G G L F S V F G A L C Y A E L G T T I K K S G A S Y A Y I LATM V I W A V G G I F S V F G A L C Y A E L G T T I K K S G A S Y A Y I HSA1 I V W A I G G L F S V V G A L C Y A E L G T T I T K S G A S Y A Y I MMU1 V F W S A C G V L S L F G A L S Y A E L G T S I K K S G G H Y T Y I MAT1 I I W A A C G I L A T L G A L C F A E L G T M I T K S G G E Y P Y L HAT1 I I W A A C G V L A T L G A L C F A E L G T M I T K S G G E Y P Y L E16C I V W L I S G I F T A I G A Y C Y A E L G T L I K K S G G D Y A Y I CEL2 I V W V L S G L F A G I G A F C Y A E L G T L I R K S G G D Y A Y I CEL1 L I W L L S G V F A M I G A V C Y S E L G T L I P K S G G D Y A Y I HLT3 SMA1 I M W A V T G L F S T L G A I V Y A E L G V T I P R S G G E Y V Y I CEL4 L V W I G C G L I S L I G G I C Y I E L G T S I H D P G C D F A Y T CEL5 I Q I Q G A G V E L D E T S CEL6 C L W A L C A C I S L F G A L S Y V E L G T S I R K S G C D F A Y L S CEL3 L I W V L C A V I A I L G A I C Y I E L G T S I R E A G C D F A Y I YKBA F A W L L G G I L T L A G G L T I A E I G T Q I P K T G G L Y T Y L MUP1 I M W A V G A I I A I S G L Y V Y M E F G T A I P K N G G E K N Y YHD6 A I W V F S A A I A F A G L Y L F L E F G S W I P K S G G R K N F L 4F2M LATR E16H ASUR MLT2 HLT2 HSA2 LATM HSA1 MMU1 MAT1 HAT1 E16C CEL2 CEL1 HLT3 SMA1 CEL4 CEL5 CEL6 H F G S T Q T L N T L R Q N A Q I L V I C E K K C V E L K F T L D F T CEL3 YKBA MUP1 YHD6 4F2M L E V Y G S L P A F LATR L E V Y G S L P A F E16H L E V Y G S L P A F ASUR L E V Y G A L P A F MLT2 K D I F G G L A G F HLT2 K D I F G G L A G F HSA2 L E A F G G F L A F LATM L E A F G G F L A F HSA1 L E A F G G F I A F MMU1 L E V F G P L L A F MAT1 M E A F G P I P A Y HAT1 M E A Y G P I P A Y E16C M E A F G P F V A F CEL2 M E A F G P F L A F CEL1 Y E A F G P L P S F HLT3 SMA1 L Q T F G P L L A F CEL4 V Y V G W E G I A F CEL5 CEL6 Q N S E K N F I I F F R K F M S F R L K K L R F L K S F T P I F L T F CEL3 C Y V K W Y S I A F YKBA E E V Y G E F W G F MUP1 L E A I F R K P K F F YHD6 E R S F E R P R L 4F2M L LATR L E16H L ASUR L MLT2 L HLT2 L HSA2 I LATM I HSA1 I MMU1 V MAT1 L HAT1 L E16C I CEL2 L CEL1 L HLT3 SMA1 L CEL4 S CEL5 CEL6 I T Q N V T K I A I I S Q F F H T K N A T K S H R T H F S V I T K N A CEL3 A YKBA L MUP1 I YHD6 L 4F2M K L W I E L L I I R P S S Q Y I V A LATR K L W I E L L I I R P S S Q Y I V A E16H K L W I E L L I I R P S S Q Y I V A ASUR K L W V E L L I I R P S S Q Y I V A MLT2 R L W I A V L V I Y P T N Q A V I A HLT2 R L W I A V L V I Y P T N Q A V I A HSA2 R L W T S L L I I E P T S Q A I I A LATM R L W T S L L I I E P T S Q A V I A HSA1 R L W V S L L V V E P T G Q A I I A MMU1 R V W V E L L V I R P G A T A V I S MAT1 F S W T S L I V M K P S S F A I I C HAT1 F S W A S L I V I K P T S F A I I C E16C R L W I E A I V V R P C T V T I V A CEL2 R L W I E S I V V R P C T A T I V A CEL1 F L W V A L V I I N P T S L A I I A HLT3 R A T SMA1 A F W I T F V V I G S A S C A A N A CEL4 F M W V G V I M S F P A S A A V Q A CEL5 E F W A K CEL6 K N P D F P K N I F R R P L A S S F M W V S T C L S Y P A V L A I Q A CEL3 F M W V S V L M T Y P A T I A I C A YKBA C G W V Q I I I Y G P A I I G A L G MUP1 T C M Y A A Y I F F L G W A A G N S YHD6 I S V V F S C Y S V L T G Y A L T G S 4F2M L V F A T Y L L LATR L V F A T Y L L E16H L V F A T Y L L ASUR L V F A T Y L L MLT2 L T F S N Y V L HLT2 L T F S N Y V L HSA2 I T F A N Y M V LATM I T F A N Y M V HSA1 I T F A N Y I I MMU1 L A F G R Y I L MAT1 L S F S E Y V C HAT1 L S F S E Y V C E16C L T F A I Y G L CEL2 L T F A I Y M L CEL1 I T C A T Y A L HLT3 SMA1 L I F A Q Y I L CEL4 L T F V A G M CEL5 CEL6 I S F G E Y I V T E K K T K I L K K K K F F S K F L N F L F K Y T V S CEL3 E T F G Q Y L I YKBA L Y F G S L M MUP1 I N T A I M F L YHD6 I V F G K Y V L 4F2M K P V F P T C P V P E E A A LATR K P V F P T C P V P E E A A E16H K P L F P T C P V P E E A A ASUR K P V F P T C P V P D D A A MLT2 Q P L F P T C F P P E S G L HLT2 Q P L F P T C F P P E S A HSA2 Q P L F P S C F A P Y A A S LATM Q P L F P S C G A P Y A A G HSA1 Q P S F P S C D P P Y L A C MMU1 E P F F I Q C E I P E L A I MAT1 A A F Y S G C K P P A V V V HAT1 A P F Y V G C K P P Q I V V E16C R P F F P D C A P P D V V A CEL2 K P F Y P D C D S P P L S T CEL1 Q P F Y S C P V P D V V V HLT3 A S SMA1 R P V Y M D C V T P T I V I CEL4 A P I W P L E H P W D G I I E CEL5 CEL6 Y F I L K I S F F K H L I I K F F Q G L D S W I T I D E N W R F M T Y CEL3 E G L K Q Y Y E I D D A L V P T C Q YKBA A N L F G W G S G L S MUP1 T A A D T E V T K W N Q YHD6 S A F G V T D D S W S 4F2M K L V A C L C V L L L T A V N C Y S V K A A T R V Q D A F A A A K_L LATR K L V A C L C V L L L T A V N C Y S V K A A T R V Q D A F A A A K_L E16H K L V A C L C V L L L T A V N C Y S V K A A T R V Q D A F A A A K_L ASUR K I V A C L C I L L L T A I N C Y S V K A A T R V Q D A F A A A K_L MLT2 R L L A A I C L L L L T W V N C S S V R W A T R V Q D I F T A G K_L HLT2 R L L A A I C L L L L T W V N C S S V R W A T R V Q D I F T A G K_L HSA2 R L L A A A C I C L L T F I N C A Y V K W G T L V Q D I F T Y A K_V LATM R L L A A A C I C L L T F I N C A Y V K W G T L V Q D I F T Y A K_V HSA1 R L L A A A C I C L L T F V N C A Y V K W G T R V Q D T F T Y A K_V MMU1 K L V T A V G I T V V M V L N S T S V S W S A R I Q I F L T F C K_L MAT1 K L L A A A A I L F I T T V N A L S V R L G S Y V Q N V F T A A K_M HAT1 K C L A A A A I L F I S T V N S L S V R L G S Y V Q N I F T A A K_L E16C E L L A I L L I V L M T A I N C I S V R L A T I V Q D W F T I A K_V CEL2 E L I A A L L L V L L T A V N C I S V K W A S K V Q D F F F V T K_T CEL1 N L F A G C I I A V L T F I N C W D V R M A T R T N D F F T I T K_L HLT3 R V L S M A C L M L L T W V N S S S V R A A T R I Q V I F T G G K_L SMA1 R T V A V L G L L L L C F V H C F S V K L A T K V A V V F T A C K_V CEL4 K G L G F A L I I V L T I L N L Y A I D K Y A S K F Q I V V T I A K_M CEL5 K L L G F S L I I L L M F M N F F S L K T F V Q R F S I L A S L A K_I CEL6 R L V G F S M L W P L M L L N F F S L K K V A G A F Q I V A T A I K_L CEL3 K L F A Y S L L F L V T W M N F F E L S K F A A R F Q I L A T I A K_L YKBA K V I G I I A V L F L C V I N I I G T K Y G G F V Q T L T T I G K_L MUP1 R G I G V A V V F F A F L I N S L N V K I G L Y L Q N I L G I F K_I YHD6 K Y V S I S F I I F A V L I H G V S V R H G V F I Q N A L G G L K_L 4F2M L A L A L I I L L G_F I Q M G K D M G Q G D A S N L Q Q K L S F E LATR L A L A L I I L L G_F I Q M G K D I G Q G D A S N L H Q K L S F E E16H L A L A L I I L L G_F V Q I G K G D V S N L D P K F S F E ASUR L A L F L I I I L G_F V Q L G K G G V E D L K P E R S F E MLT2 L A L A L I I I M G_I V Q I C K G E F F W L E P K N A F E HLT2 L A L A L I I I M G_I V Q I C K G E Y F W L E P K N A F E HSA2 L A L I A V I V A G_I V R L G Q G A S T H F E N S F E LATM L A L I A V I I A G_I V R L G Q G A T A N F E N S F E HSA1 V A L I A I I V M G_L V K L C Q G H S E H F Q D A F E MMU1 T A I L I I I V P G_V I Q L I K G Q T H H F K D A F S MAT1 V I V A I I I I S G_L V F L A Q G N V K N F Q N S F E HAT1 V I V A I I I I S G_L V L L A Q G N T K N F D N S F E E16C V A L C L I I L T G_L G L L F F G E S Q Y K D S F E N I F E CEL2 A A L V L I I F T G_L W N M V S G K P E A F D S F E N I F E CEL1 I A L T L I I T C G_G Y W L S L G H I D N L V M P D V A E HLT3 L A L S L I I T V G_F V Q I F Q G H F E E L R P T N A F A SMA1 T A L L I I I G F G_L Y Y L G K G N V E S F K N A F E CEL4 L S L A I I I V T G_F Y Y L I F K G Q T E Y L E H P F E CEL5 A A T L L I I I T G_F Y Y L I F K H W K Q N L E E P F K CEL6 I V A S I I I I T G_L Y H I I F K Q Q T Q N F K N S F T CEL3 F S C M L I I G T G_F Y F Y F V K G W H G Y L E N P M Q YKBA I P I A C I I V F G_L W K G D Q H I F T A V N E MUP1 G I V L F I S I T G_W V A L G G G L K D G Y Q S H N F R N A F E YHD6 I M I V L M C F A G_L Y T L F F Y K S T G Q V A W D L P V T Q V E 4F2M G T N L D V G N I V L A L Y S G L F A Y G G_W N Y L N F V T E E_M I LATR G T N L D V G N I V L A L Y S G L F A Y G G_W N Y L N F V T E E_M I E16H G T K L D V G N I V L A L Y S G L F A Y G G_W N Y L N F V T E E_M I ASUR G T S T N V G Q W V L A L Y S G L F A Y G G_W N Y L N F V V E E_M I MLT2 N F Q E P D I G L V A L A F L Q G S F A Y G G_W N F L N Y V T E E_L V HLT2 N F Q E P D I G L V A L A F L Q G S F A Y G G_W N F L N Y V T E E_L V HSA2 G S S F A V G D I A L A L Y S A L F S Y S G_W D T L N Y V T E E_I K LATM G S S F A M G D I A L A L Y S A L F S Y S G_W D T L N Y V T E E_I R HSA1 G S S W D M G N L S L A L Y S A L F S Y S G_W D T L N F V T E E_I K MMU1 G R D T S L M G L P L A F Y Y G M Y A Y A G_W F Y L N F I T E E_V D MAT1 G T Q T S V G A I S L A F Y N G L W A Y D G_W N Q L N Y I T E E_L R HAT1 G A Q L S V G A I S L A F Y N G L W A Y D G_W N Q L N Y I T E E_L R E16C N T S Q D F T K V S L A F Y S G L F A Y S G_W N F L N F I V E E_L Q CEL2 N T A K D L E T A S L A F Y S G L F A Y Q G_W N Y L N F I V E E_L Q CEL1 G S Q T K L S A I A M A F Y S G V F S F S G_F S Y L N F V T E E_L K HLT3 F W M T P S V G H L A L A F L Q G S F A F S G_W N F L N Y V T E E_L V SMA1 D S E K S P G E L A L G F Y Q G F W A F S G_W N Y L N F L T G E_V K CEL4 G S N T N P G Q I S L A F Y G A L W S F A G_W D I L N F G T P E_I R CEL5 G S N W N P G P F V N A L F A G L F S Y D G_W D I L N F G A E E_I E CEL6 G S D W N P G N L V L G V Y S G L F A Y N G_W D V L N F G A E E_I E CEL3 G S K Y G T G N L I L G F Y G G L W A F S G_W D V L N Y S T G E_I K YKBA S I S D M N F G A A I L A T L F A Y D G_W I L L A A L G G E_M K MUP1 G T E T A T A Y G I V N A L Y S V I W S F V G_Y S N V N Y A L G E_V K YHD6 K D S L L S V S S I A T A F I S S F F C F S G_W D T V H T V T S E_I K 4F2M N P_Y R N L P L A I I I S L P I V T L V Y V L T N_L A Y F T T L S T N LATR N P_Y R N L P L A I I I S L P I V T L V Y V L T N_L A Y F T T L S T N E16H N P_Y R N L P L A I I I S L P I V T L V Y V L T N_L A Y F T T L S T E ASUR E P_Y K N L P R A I I I S M P I V T L V Y V L T N_L A Y F T T L T P E MLT2 D P_Y K N L P R A I F I S I P L V T F V Y V F A N_I A Y V T A M S P Q HLT2 D P_Y K N L P R A I F I S I P L V T F V Y V F A N_V A Y V T A M S P Q HSA2 N P_E R N L P L S I G I S M P I V T I I Y I L T N_V A Y Y T V L D M R LATM N P_E R N L P L S I G I S M P I V T I I Y L L T N_V A Y Y S V L D I K HSA1 N P_E R N L P L A I G I S M P I V T L I Y I L T N_V A Y Y T V L N I S MMU1 N P_E K T I P L A I C I S M A I I T V G Y V L T N_V A Y F T T I S A E MAT1 N P_Y R N L P M A I V I G I P L V T V C Y I L M N_I A Y F T V M T P T HAT1 N P_Y R N L P L A I I I G I P L V T A C Y I L M N_V S Y F T V M T A T E16C N P_K R N L P L A I A I S I T S C T V I Y V L T N_V A L Y T A I S P D CEL2 N P_K R N L P L S I A I S C S L C T I I Y T L T N_V A L Y T S I T P D CEL1 N P_F R N L P R A I Y I S I P I V T I V Y M L V N_I A Y F S V L T V D HLT3 D P_R K N L P R A I F I S I P L V T F V Y T F T N_V A Y F T A M S P Q SMA1 N P_G R T L P I V I I L S L T T V T F I Y I L T N_V A Y L A V L S P L CEL4 N P_R R T M P I A L L G G V S I V T A V Y L A M N_I S Y M T V L T P G CEL5 N P_K R T M P L S I I I G M T C I G V I Y V A V N_V A Y S I V L S P T CEL6 N P_R R T L P I A A I S G I A I S A T V F I L M N_V S Y F S V L S V E CEL3 H P_K R N V P F A L L T G I S V V T A I Y V A I N_V A Y F V V L D V E YKBA N P_E K L L P R A M T G G L L I V T A I Y I F I N_F A L L H I L S A N MUP1 N P_V R T L K I A G P T S M V F L A I I Y I F V N_I A Y F A V V P K D YHD6 N P_V K T L K V S G P L S L I I C F V C Y T M M N_V A Y L K V L T Y E 4F2M Q M L T S E A V A V D F G N Y H L G V M S W I I LATR Q M L T S E A V A V D F G N Y H L G V M S W I I E16H Q M L S S E A V A V D F G N Y H L G V M S W I I ASUR Q M L N S E A V A V D F G N Y H L G V M A W I I MLT2 E L L A S N A V A V T F G E K L L G V M A W I M HLT2 E L L A S N A V A V T F G E K L L G V M A W I M HSA2 D I L A S D A V A V T F A D Q I F G I F N W I I LATM E I L A S D A V A V T F A D Q I F G V F N W I I HSA1 D V L S S D A V A V T F A D Q T F G M F S W T I MMU1 E L L Q S S A V A V T F S E R L L G K F S L A V MAT1 E L L Q S Q A V A V T F G D R V L Y P A S W V V HAT1 E L L Q S Q A V A V T F G D R V L Y P A S W I V E16C E M L E S P A V A V L F A N K L Y G K F A F I M CEL2 E M L A S P A V A V L F A E K N Y G W F A F C M CEL1 E I L D S D A V A I T F A D K I L G HLT3 E L L S S N A V A V T F G E K L L G Y F S W V M SMA1 E V L A S E G S T A I A V S F A S R T M G V V G L V M CEL4 Q I M N S T A V A A D F A Q I T L G G F S Y A I CEL5 E M I A S N A V A I D F A N K T L G A A A F V V CEL6 D F K N S P A V A V V R T F F I T F A E R T L G D F H Y A I CEL3 T V K Q S D A V A A I F S R E T L G D F A N V V YKBA E I V T L G E N A T S T A A T M L F G S I G G K L I MUP1 K L I S S K L I L A A D F F D I V F G G Q A K R A A YHD6 E I V S A G P L V G S V L F T K L F G P R V G G K F I 4F2M P V F V G L S C F G S V N G S L LATR P V F V G L S C F G S V N G S L E16H P V F V G L S C F G S V N G S L ASUR P V F V G L S C F G S V N G S L MLT2 P I S V A L S T F G G V N G S L HLT2 P I S V A L S T F G G V N G S L HSA2 P L S V A L S C F G G L N A S I LATM P V A V A F S C F G G L N A S I HSA1 P I A V A L S C F G G L N A S I MMU1 P I F V A L S C F G S M N G G V MAT1 P L F V A F S T I G A A N G T C HAT1 P L F V A F S T I G A A N G T C E16C P L C V A C S T I G S A N G V I CEL2 P I F V A C S T I G S A N G V I L T R L C G S R D V R Q A A I A E V A CEL1 T F G S K HLT3 P V S V A L S T F G G I N G Y L SMA1 P A L V G A S V F G S I N G E V CEL4 P F M I A L L L I G T L N S N I CEL5 P V M V A I L L I G S L N S T M CEL6 P F L I S L L L I G S M N T T I CEL3 P F L I G I L L I G S L N S N L YKBA S V G I I V S I F G C L N G K V MUP1 A A L V G L S A L G N V L S V I YHD6 A F S I A I S A A S N I L V V I 4F2M LATR E16H ASUR MLT2 HLT2 HSA2 LATM HSA1 MMU1 MAT1 HAT1 E16C CEL2 E P Q N P K I F G N R Q L P N L T S Q K I F G N R Q L P F F E N F F V CEL1 HLT3 SMA1 CEL4 CEL5 CEL6 CEL3 YKBA MUP1 YHD6 4F2M F T S S R L F F V G S R E G H L P LATR F T S S R L F F V G S R E G H L P E16H F T S S R L F F V G S R E G H L P ASUR F T S S R L F F V G A R E G H L P MLT2 F T S S R L F F A G A R E G H L P HLT2 F T S S R L F F A G A R E G H L P HSA2 V A A S R L F F V G S R E G H L P LATM V A A S R L L F V G S R E G H L P HSA1 F A S S R L F F V G S R E G H L P MMU1 F A V S R L F Y V A S R E G H L P MAT1 F T A G R L I Y V A G R E G H M L HAT1 F T A G R L I Y V A G R E G H M L E16C F T S A R L F Y S G A R E G Q M P CEL2 E I I F L S A L E K S M V V F F F Y S E T L F Y C G A R E G Q M P CEL1 I L M P L M F F S G A R N S Q L P HLT3 F T S S R L C F S G A R E G H L P SMA1 F S I S R L A F T A G E E G H M P CEL4 F C G S R F T H A A A R E G H L P CEL5 F S A S R Y L Q A V S R Q G H I P CEL6 F A C S R Y M Y S G A Q Q S V M P CEL3 F S G S R Y M Y A A A R Q G H L P YKBA L S F P R V S F A M A E R K Q L P F A MUP1 F S Q G R I I Q Q L G R E G V L P F S YHD6 Y S I S R V N Q E I F K E G Y L P F S 4F2M S V L S M I H P Q L L T P_V P S L V F T C I M T L M Y A F S R LATR S I L S M I H P Q L L T P_V P S L V F T C V M T L M Y A F S R E16H S I L S M I H P Q L L T P_V P S L V F T C V M T L L Y A F S K ASUR S L L A M I H P R L L T P_M P S L I F T C A M T L L Y A F S N MLT2 S V L A M I H V K R C T P_I P A L L F T C L S T L L M L V T S HLT2 S V L A M I H V K R C T P_I P A L L F T C I S T L L M L V T S HSA2 D A I C M I H V E R F T P_V P S L L F N G I M A L I Y L C V E LATM D A I C M V H V E R F T P_V P S L L F N G V L S L V Y L C V E HSA1 D L L S M I H I E R F T P_I P A L L F N C T M A L I Y L I V E MMU1 E I L S M I H V H K H T P_L P A V I V L H P L T M V M L F S G MAT1 K V L S Y I S V K R L T P_A P A L I F Y G I I A I I Y I I P G HAT1 K V L S Y I S V R R L T P_A P A I I F Y G I I A T I Y I I P G E16C A V L T M I N K K T K T P_I P A V I L T G A L S I A Y L L A S K CEL2 N V L T M V N K T T K T P_I P A V I L T G L L S L L Y L L L S N CEL1 E L F A M I S I R Q L T P_I P S L I F L G G T S I V M L F I G HLT3 S F L A M I H V R R C T P_I P A L L V C C G A T A V I M L V G SMA1 A L L S M V N I D R L T P_I P S I L I V V T L S V I F Q M F D CEL4 T F L S C I N E E S N S P_R A A L L F Q L V C T V V V T F I CEL5 S A I S G I A P N C D S P_R V A L L V H I L I A I A V S F L G CEL6 T P L R G I H H R T R S P_R L A V F A E I L I A I C L S F I G CEL3 A C F S C V N T E T E S P_R V A V L A Q S V L A L V I S Y I G YKBA E K L S H V H P S F R T P_W I A I S F Q I A L A L I M M L I S MUP1 N F F A S S K P F N S P_M V G L F Q H F I V C T V T I L A P P P G YHD6 I H M S K N W P F D A P_L P S I S L C G F I T I A W I L I L P K E G 4F2M D I F S I I N F F S F F N W L C V A L A I I G M M W L R F K K P E LATR D I F S I I N F F S F F N W L C V A L A I I G M M W L R F K K P E E16H D I F S V I N F F S F F N W L C V A L A I I G M I W L R H R K P E ASUR D I F S V I N F F S F F N W L C V A L A I I G M M W L R Y K K P E MLT2 D M Y T L I N Y V G F I N Y L F Y G V T V A G Q I V L R W K K P D HLT2 D M Y T L I N Y V G F I N Y L F Y G V T V A G Q I V L R W K K P D HSA2 D I F Q L I N Y Y S F S Y W F F V G L S I V G Q L Y L R W K E P D LATM D I F Q L I N Y Y S F S Y W F F V G L S I V G Q L Y L R W K D P D HSA1 D V F Q L I N Y F S F S Y W F F V G L S V V G Q L Y L R W K E P K MMU1 D L Y S L L N F L S F A R W L F M G L A V A G L I Y L R Y K R P D MAT1 D I N S L V N Y F S F A A W L F Y G M T I L G L V V M R F T R K D HAT1 D I N S L V N Y F S F A A W L F Y G L T I L G L I V M R F T R K E E16C D V Y Q L I N Y I Q I S Y W L A I G T A I A A L F W L R R T M P D CEL2 N I Y S L I N Y I Q V S Y W I A I G G A I L A L F Y F R K T M P D CEL1 N V F Q L I N Y L S F A E S L V V F S S V A G L L K L R F T M P E HLT3 D T Y T L I N Y V S F I N Y L C Y G V T I L G L L V L R W R R P A SMA1 D I L Y L I E L T G F A F S V M S A M A V C S L L Y I R R T N P E CEL4 D T N S L I N Y V S F V M F G Q R V F T M T A L M W I R Y R N I P V CEL5 D P D K L I N Y V A F A Q W S Q R A F T M S A L L Y L R I R G R P R CEL6 N L D Q L I S Y M S F A L W S Q R T C T Q V G F I Y F K L R G T L K CEL3 D L D T L I T Y V M F G F W A Q R I F S L V A L L I I R H N H I P V YKBA N P D K L S E I S I F M I Y I F Y V M A F F A V F I L R K R A K G E MUP1 D A Y L L V Q N L I S Y P M N I I N F A I S A G L L W I Y W Q R R Q G YHD6 E S F N Y L V S M D G Y G N Q F F L L L V A I G L F I W R F K H K N E 4F2M L E R P I K V N L A L P V F F I L A C L F L I A V S LATR L E R P I K V N L A L P V F F I L A C L F L I A V S E16H L E R P I K V N L A L P V F F I L A C L F L I A V S ASUR L E R P I K V N I L L P I F F I L A C I F L I V V S MLT2 I P R P I K V S L L F P I I Y L L F W A F L L I F S HLT2 I P R P I K I N L L F P I I Y L L F W A F L L V F S HSA2 R P R P L K L S V F F P I V F C L C T I F L V A V P LATM R P R P L K L S L F F P I I F C L C T I F L V A V P HSA1 R P R P L K L S V F F P I V F C I C S V F L V I V P MMU1 M H R P F K V P L F I P A L F S F T C L F M V V L S MAT1 L E R P I K V P L F I P I I V I L V S L F L I L A P HAT1 L E R P I K V P V V I P V L M T L I S V F L V L A P E16C A S R P I K V P L I W P A I F L A G C I A L V L I P CEL2 A P R A V K A P I V F P I I F F I G C V L L V L V P CEL1 N V L N A R P I K I S L L W P I L F F L M C L F L L I L P HLT3 L H R P I K V N L L V P V V Y L V F W A F L L V F S SMA1 M N T S G F K L P I F F P V L Y L I V D I A I G I L A CEL4 H P D A I R V P L I F S F L F W L I T I A L V V V P F I E E CEL5 H P D R I Q L P I I M P I L F F L V C T S M V V I S CEL6 T Q D S F Q V P I F V P V V F L G I C I A L L V I P CEL3 H P D A V R V P L F C I Y L F L A I T V A L V I I P YKBA K R A Y S V P L Y P F M P I L A I A G S F F V L G S T MUP1 K I E W N P P I K A G V F V T G F F T L S N L Y L I I A P YHD6 V P E I R A S T F G V L A I I T L S L Y M L M A P 4F2M F W K T P M E C G I G LATR F W K T P L E C G I G E16H F W K T P V E C G I G ASUR F Y M T P V E C G I G MLT2 L W S E P V V C G I G HLT2 L W S E P V V C G I G HSA2 L Y S D T I N S L I G LATM L Y S D T I N S L I G HSA1 L F T D T I N S L I G MMU1 L Y S D P F S T G V G MAT1 I I S E P A W E Y L Y C HAT1 I I S K P T W E Y L Y C E16C M V A A P R D T G I G CEL2 V L G N P K D T A I G CEL1 F F H S D P W E L I Y G HLT3 F I S E P M V C G V G SMA1 I Y Q K P T D C A V S CEL4 F T V G V T D L P N L E K F Q N V Q L I S E K F Q Q T I V G CEL5 I I D D F K S S A V G CEL6 I T Q N Y H V A I Y G CEL3 I F Y E F Q S T A L A YKBA L I T D T M S C G L S MUP1 Y V P P S N G E S V Y S S M P Y W I H C V I A YHD6 F F A D P S L N R V G F L P P Y Q 4F2M F A I I L S G L P V Y F F G V W W K N K P K W I L Q A I F S V LATR F A I I L S G L P V Y F F G V W W K N K P K W I L Q V I F S V E16H F T I I L S G L P V Y F F G V W W K N K P K W L L Q G I F S T ASUR F I I I L T G V P V Y F F G V W W Q N K P D W I L H G I H S S MLT2 L A I M L T G V P V Y F L G V Y W Q H K P K C F N D F I K S L HLT2 L A I M L T G V P V Y F L G V Y W Q H K P K C F S D F I E L L HSA2 I A I A L S G L P F Y F L I I R V P E H K R P L Y L R R I V G S A LATM I G I A L S G L P F Y F F I I R V P E H K R P L F L R R I V A S I HSA1 I G I A L S G V P F Y F M G V Y L P E S R R P L F I R N V L A A I MMU1 F L I T L T G V P A Y Y L F I V W D K K P K W F R R L S D R I MAT1 V L F I L S G L I F Y F L F V Y Y K F G W A Q R I S R P V HAT1 V L F I L S G L L F Y F L F V H Y K F G W A Q K I S K P I E16C L L I M L S A V P V Y G I F I G W K N K P K W F N E F I D S S CEL2 I L I M L S G V P V Y L I F I A W K G K P K C I D S L T D S V CEL1 V F L V L S G I P I Y V L F V Y N K Y R P G F I Q S V W I G F HLT3 I I I I L T G V P I F F L G V F W R S K P K C V H R F T E S M SMA1 L G V M L L G V P V Y L F G V V W K N K P R S M R S L I Y G V CEL4 V G L V L M G V F L Y I I F M K P M K L P E F L I R F N D S M CEL5 L G I L L G G L I I F I I F V W D R A L P S S H T F R N A T H V I CEL6 V S M T I G G A I I Y L I F I F P N T L P I F L H K I N N S I CEL3 I A I C L F G F V L Y Y V F I H K A I F P R W L V A L N K K V YKBA I L I G L A G L P V Y Y G M K K R K A S MUP1 W G I F F F G G V Y Y V V W A Q L L P R W G H Y K L V S K D V YHD6 I M S L L V I V A C F F F W L V K F V L L P K F F H Y K L L P K I 4F2M T V L C Q K L M Q V V P LATR T V L C Q K L M Q V V P E16H T V L C Q K L M Q V V P ASUR T A L L Q K V M E A V P MLT2 T L V S Q K M C V V V Y P HLT2 T L V S Q K M C V V V Y P HSA2 T R Y L Q V L C M S V A A LATM T R Y L Q I L C M S V A A HSA1 T R G T Q Q L C F C V L T MMU1 T R T L Q I I L E V V P MAT1 T K H L Q M L M E V V P P HAT1 T M H L Q M L M E V V P P E16C T V F I Q K L F M V V D E CEL2 T I F T Q K L F M V V D A CEL1 T H F I Q K L F Y C V P HLT3 T R W G Q E L C F V V Y P SMA1 T I T L Q K V L K V V E Q CEL4 T R I T C K I L F T T P D L K H H S CEL5 N E E S T K F M Q I I F N V V P CEL6 V K F A Q I I F N C V I E P Y CEL3 T L W C C I L F D C L P D V K G G V Q L L A S D S S Q A L L S YKBA MUP1 L G E D G F W R V K I A K V Y D YHD6 T Y L H D G L I V T 4F2M Q E T LATR Q E T E16H Q E T ASUR Q E S MLT2 Q E G N S G A E E T T D D L E E Q H K P I F K P T P V K D HLT2 E V E R G S G T E E A N E D M E E Q Q Q P M Y Q P T P T K D HSA2 E M D L E D G G E M P K Q R D LATM E M D L E D G E L S K Q D HSA1 E L D V A E E K K D MMU1 E D S K E L MAT1 E K D P E HAT1 E E D P E E16C D K E D CEL2 N K E E CEL1 E L S S S HLT3 Q G S L E E E E N A P W A S P P H C SMA1 E K V S D I I E L D G H L K P V D CEL4 E T R T L K S E N S G E T V V T R F N Y E A V A S Q D D R T K L P T CEL5 E R V G D E E M K N A I G G A E S E S E K V P A Y K I S P T G N G Q CEL6 E D S T V E E F E E F E E I N D CEL3 E R L S S T R L S D D S F P D L H S D E K N I M R R N G S A A G L K M YKBA MUP1 D T I G D V D T Q E D G V I E T N I I E H Y K S E Q YHD6 E W V K K 4F2M LATR E16H ASUR MLT2 P D S E E Q P HLT2 K D V A G Q P Q P HSA2 P K S N LATM P K S K HSA1 E R K T D MMU1 MAT1 HAT1 E16C CEL2 CEL1 HLT3 P S R T S P SMA1 S Q L D I S CEL4 T H V D E T G F CEL5 F K C T R M CEL6 Y S K K F H R F CEL3 L I S S V P S S L V D L I S D V Q YKBA MUP1 E K S L YHD6 P C L C -- Results -- Length of sequences with gaps = 892 Average sequence length: 512 Percent identity (based on aligned regions): 4F2M LATR E16H ASUR MLT2 HLT2 HSA2 LATM HSA1 MMU1 MAT1 HAT1 E16C CEL2 CEL1 HLT3 SMA1 CEL4 CEL5 CEL6 CEL3 YKBA MUP1 YHD6 4F2M 0.00 98.24 92.48 80.40 53.63 53.63 50.51 49.69 47.48 45.97 44.61 43.98 47.75 45.08 45.18 48.39 41.21 31.49 33.33 30.77 29.16 30.91 23.15 21.53 LATR 98.24 0.00 92.87 80.59 53.63 53.23 50.10 49.69 47.48 45.77 43.98 43.78 47.54 44.88 45.39 48.09 41.21 31.49 32.82 30.98 29.16 30.44 23.15 21.33 E16H 92.48 92.87 0.00 80.40 54.77 54.16 49.69 49.09 47.78 45.84 44.38 44.19 48.25 44.74 44.30 49.56 40.84 31.96 33.16 31.91 30.02 30.91 23.79 21.95 ASUR 80.40 80.59 80.40 0.00 53.75 53.85 48.68 47.56 46.48 44.83 43.04 41.49 47.12 44.86 45.61 49.85 40.46 32.72 33.16 31.48 28.31 29.27 22.98 21.34 MLT2 53.63 53.63 54.77 53.75 0.00 92.03 47.40 46.89 47.11 43.61 44.63 43.39 48.77 43.76 42.79 65.29 39.56 29.98 29.65 28.99 27.66 31.54 23.62 21.22 HLT2 53.63 53.23 54.16 53.85 92.03 0.00 47.91 47.09 47.02 43.93 44.63 43.39 48.26 43.76 42.58 64.84 39.56 28.85 30.28 28.93 27.64 31.07 22.40 21.18 HSA2 50.51 50.10 49.69 48.68 47.40 47.91 0.00 90.50 72.22 43.38 43.75 42.44 43.66 42.53 45.73 41.57 37.68 32.53 32.03 32.02 30.18 30.44 26.65 23.93 LATM 49.69 49.69 49.09 47.56 46.89 47.09 90.50 0.00 70.38 43.67 43.12 41.61 43.87 42.86 46.17 40.68 38.45 33.54 33.42 32.08 30.43 30.68 25.65 23.27 HSA1 47.48 47.48 47.78 46.48 47.11 47.02 72.22 70.38 0.00 44.42 41.86 42.47 44.12 44.03 45.83 42.61 39.92 33.00 32.59 34.17 31.66 31.85 24.45 22.38 MMU1 45.97 45.77 45.84 44.83 43.61 43.93 43.38 43.67 44.42 0.00 42.92 43.54 42.09 40.74 39.12 43.57 39.87 32.92 34.52 36.03 30.80 31.15 22.11 21.77 MAT1 44.61 43.98 44.38 43.04 44.63 44.63 43.75 43.12 41.86 42.92 0.00 86.31 43.28 40.04 40.97 42.65 36.97 31.39 31.98 32.20 29.46 29.79 27.41 22.46 HAT1 43.98 43.78 44.19 41.49 43.39 43.39 42.44 41.61 42.47 43.54 86.31 0.00 41.81 39.04 39.69 42.35 36.97 30.35 29.95 33.05 28.42 29.11 26.72 22.46 E16C 47.75 47.54 48.25 47.12 48.77 48.26 43.66 43.87 44.12 42.09 43.28 41.81 0.00 68.99 44.15 41.11 39.66 30.98 33.59 31.61 31.39 28.34 22.45 20.08 CEL2 45.08 44.88 44.74 44.86 43.76 43.76 42.53 42.86 44.03 40.74 40.04 39.04 68.99 0.00 42.01 37.03 41.21 30.91 31.73 32.20 31.74 28.47 21.41 19.04 CEL1 45.18 45.39 44.30 45.61 42.79 42.58 45.73 46.17 45.83 39.12 40.97 39.69 44.15 42.01 0.00 39.69 36.90 31.21 29.44 31.56 31.21 28.19 25.00 23.99 HLT3 48.39 48.09 49.56 49.85 65.29 64.84 41.57 40.68 42.61 43.57 42.65 42.35 41.11 37.03 39.69 0.00 34.17 31.11 29.38 28.53 28.61 26.64 22.54 23.03 SMA1 41.21 41.21 40.84 40.46 39.56 39.56 37.68 38.45 39.92 39.87 36.97 36.97 39.66 41.21 36.90 34.17 0.00 27.82 28.09 28.78 29.84 28.67 23.47 22.11 CEL4 31.49 31.49 31.96 32.72 29.98 28.85 32.53 33.54 33.00 32.92 31.39 30.35 30.98 30.91 31.21 31.11 27.82 0.00 36.72 37.17 39.33 26.35 21.26 18.57 CEL5 33.33 32.82 33.16 33.16 29.65 30.28 32.03 33.42 32.59 34.52 31.98 29.95 33.59 31.73 29.44 29.38 28.09 36.72 0.00 41.11 39.03 24.23 20.99 19.85 CEL6 30.77 30.98 31.91 31.48 28.99 28.93 32.02 32.08 34.17 36.03 32.20 33.05 31.61 32.20 31.56 28.53 28.78 37.17 41.11 0.00 38.48 25.94 20.70 18.94 CEL3 29.16 29.16 30.02 28.31 27.66 27.64 30.18 30.43 31.66 30.80 29.46 28.42 31.39 31.74 31.21 28.61 29.84 39.33 39.03 38.48 0.00 26.93 21.48 18.98 YKBA 30.91 30.44 30.91 29.27 31.54 31.07 30.44 30.68 31.85 31.15 29.79 29.11 28.34 28.47 28.19 26.64 28.67 26.35 24.23 25.94 26.93 0.00 18.78 23.71 MUP1 23.15 23.15 23.79 22.98 23.62 22.40 26.65 25.65 24.45 22.11 27.41 26.72 22.45 21.41 25.00 22.54 23.47 21.26 20.99 20.70 21.48 18.78 0.00 23.62 YHD6 21.53 21.33 21.95 21.34 21.22 21.18 23.93 23.27 22.38 21.77 22.46 22.46 20.08 19.04 23.99 23.03 22.11 18.57 19.85 18.94 18.98 23.71 23.62 0.00 Distance scores for phylogenetic tree: 4F2M LATR E16H ASUR MLT2 HLT2 HSA2 LATM HSA1 MMU1 MAT1 HAT1 E16C CEL2 CEL1 SMA1 HLT3 CEL4 CEL3 CEL5 CEL6 YKBA MUP1 YHD6 4F2M 0.00 0.96 7.18 17.67 56.09 56.90 61.42 61.22 62.92 62.73 69.97 71.07 63.02 77.64 74.80 78.16 94.28 112.92 116.37 118.25 132.54 119.77 143.58 149.27 LATR 0.96 0.00 7.19 17.57 55.93 56.96 61.38 61.07 62.64 63.05 69.99 70.83 63.07 77.76 74.54 77.77 94.36 113.02 116.30 119.09 132.18 120.32 143.44 149.76 E16H 7.18 7.19 0.00 16.53 55.10 56.04 62.15 61.60 62.49 63.41 69.82 70.07 61.89 77.77 74.88 77.59 92.62 113.91 116.10 119.76 132.09 119.83 145.21 150.89 ASUR 17.67 17.57 16.53 0.00 56.74 57.11 64.74 65.41 64.98 64.32 70.51 73.39 64.43 78.27 73.36 78.57 89.22 113.10 119.56 117.36 133.52 122.69 148.44 155.36 MLT2 56.09 55.93 55.10 56.74 0.00 8.33 64.73 66.38 63.52 73.36 75.02 76.33 69.89 82.99 81.34 79.93 64.83 112.21 117.41 123.81 137.59 117.42 148.94 152.09 HLT2 56.90 56.96 56.04 57.11 8.33 0.00 63.60 66.25 63.94 73.39 75.68 77.58 69.63 83.97 82.70 81.46 65.68 115.38 116.54 121.92 140.53 118.08 150.28 152.38 HSA2 61.42 61.38 62.15 64.74 64.73 63.60 0.00 8.56 26.45 66.79 70.89 73.59 72.75 84.03 76.38 83.14 102.31 109.85 108.89 118.64 122.69 117.62 140.24 146.21 LATM 61.22 61.07 61.60 65.41 66.38 66.25 8.56 0.00 27.47 66.82 70.90 72.75 72.86 83.79 74.71 81.36 104.09 108.57 109.57 116.54 122.56 117.59 140.48 148.40 HSA1 62.92 62.64 62.49 64.98 63.52 63.94 26.45 27.47 0.00 66.42 72.52 73.56 73.61 80.94 74.52 80.97 100.69 106.33 109.05 115.36 119.69 116.81 142.56 151.52 MMU1 62.73 63.05 63.41 64.32 73.36 73.39 66.79 66.82 66.42 0.00 70.92 70.98 71.44 83.61 83.23 78.04 102.47 113.20 110.77 116.73 119.40 116.23 141.71 151.79 MAT1 69.97 69.99 69.82 70.51 75.02 75.68 70.89 70.90 72.52 70.92 0.00 11.24 75.52 88.50 76.20 83.59 106.47 113.85 111.16 119.21 122.51 117.43 138.48 146.26 HAT1 71.07 70.83 70.07 73.39 76.33 77.58 73.59 72.75 73.56 70.98 11.24 0.00 77.23 90.02 77.85 84.67 109.06 116.21 114.61 123.39 122.82 118.48 138.17 149.70 E16C 63.02 63.07 61.89 64.43 69.89 69.63 72.75 72.86 73.61 71.44 75.52 77.23 0.00 41.31 74.27 80.32 109.45 112.85 111.33 122.15 129.72 121.05 151.17 156.02 CEL2 77.64 77.76 77.77 78.27 82.99 83.97 84.03 83.79 80.94 83.61 88.50 90.02 41.31 0.00 85.91 88.83 125.35 121.14 123.48 133.66 135.51 134.37 167.63 171.07 CEL1 74.80 74.54 74.88 73.36 81.34 82.70 76.38 74.71 74.52 83.23 76.20 77.85 74.27 85.91 0.00 86.88 114.58 121.47 120.70 131.06 134.75 130.15 153.15 162.35 SMA1 78.16 77.77 77.59 78.57 79.93 81.46 83.14 81.36 80.97 78.04 83.59 84.67 80.32 88.83 86.88 0.00 116.06 116.05 113.75 123.08 132.96 118.91 146.50 156.26 HLT3 94.28 94.36 92.62 89.22 64.83 65.68 102.31 104.09 100.69 102.47 106.47 109.06 109.45 125.35 114.58 116.06 0.00 140.77 147.88 126.63 163.16 157.23 174.77 177.05 CEL4 112.92 113.02 113.91 113.10 112.21 115.38 109.85 108.57 106.33 113.20 113.85 116.21 112.85 121.14 121.47 116.05 140.77 0.00 85.60 102.83 111.54 144.68 154.50 182.10 CEL3 116.37 116.30 116.10 119.56 117.41 116.54 108.89 109.57 109.05 110.77 111.16 114.61 111.33 123.48 120.70 113.75 147.88 85.60 0.00 97.89 106.21 145.77 156.43 174.89 CEL5 118.25 119.09 119.76 117.36 123.81 121.92 118.64 116.54 115.36 116.73 119.21 123.39 122.15 133.66 131.06 123.08 126.63 102.83 97.89 0.00 110.96 147.10 157.91 185.53 CEL6 132.54 132.18 132.09 133.52 137.59 140.53 122.69 122.56 119.69 119.40 122.51 122.82 129.72 135.51 134.75 132.96 163.16 111.54 106.21 110.96 0.00 152.85 171.01 191.29 YKBA 119.77 120.32 119.83 122.69 117.42 118.08 117.62 117.59 116.81 116.23 117.43 118.48 121.05 134.37 130.15 118.91 157.23 144.68 145.77 147.10 152.85 0.00 172.97 155.68 MUP1 143.58 143.44 145.21 148.44 148.94 150.28 140.24 140.48 142.56 141.71 138.48 138.17 151.17 167.63 153.15 146.50 174.77 154.50 156.43 157.91 171.01 172.97 0.00 132.14 YHD6 149.27 149.76 150.89 155.36 152.09 152.38 146.21 148.40 151.52 151.79 146.26 149.70 156.02 171.07 162.35 156.26 177.05 182.10 174.89 185.53 191.29 155.68 132.14 0.00 Branching order: (4F2M,LATR)E16H)ASUR)MLT2)HLT2)HSA2)LATM)HSA1)MMU1)MAT1)HAT1) E16C)CEL2)CEL1)SMA1)HLT3)CEL4)CEL3)CEL5)CEL6)YKBA)MUP1) YHD6) Clusters: (MLT2,HLT2) (HSA2,LATM)HSA1) (MAT1,HAT1) (E16C,CEL2) (CEL4,CEL3)CEL5)CEL6) (MUP1,YHD6) A)4F2M 4F2MMU B)LATR LAT1RNO C)E16H E16HSA D)ASUR ASUR4XLA E)MLT2 MLAT2 F)HLT2 HLAT2 G)HSA2 ORF2HSA H)LATM LAT1MMU I)HSA1 ORF1HSA J)MMU1 ORF1MMU K)MAT1 MB0AT L)HAT1 HB0AT M)E16C E16CEL N)CEL2 ORF2CEL O)CEL1 ORF1CEL P)SMA1 ORF1SMA Q)HLT3 HLAT3 R)CEL4 ORF4CEL S)CEL3 ORF3CEL T)CEL5 ORF5CEL U)CEL6 ORF6CEL V)YKBA YKBABSU W)MUP1 MUP1SCE X)YHD6 YHD6SCE Branch lengths: (r1,r2,r3,r4,r5) (r6,r7,........) 0.47 0.49 3.14 3.57 4.33 9.33 18.90 3.84 4.49 25.01 4.15 4.24 4.32 9.38 13.30 17.82 1.53 33.39 1.77 4.78 6.46 31.61 -1.95 14.46 26.85 21.88 -0.62 43.32 4.26 42.39 -2.97 63.20 11.77 42.61 42.99 4.81 52.75 -1.11 61.35 20.13 5.25 68.28 29.97 61.79 70.35 % s.d. (observed vs calculated) = 5.73