-- PROGRESSIVE (similarity) ALIGNMENT -- Blosum62 Sequences are entered in the following order: 1)CT1M CATMMU 2)CT3R CAT3RNO 3)CT1R CAT1RNO 4)ERRM ERRMAU 5)CT1H CAT1HSA 6)CT2H CAT2HSA 7)CT2M CAT2MMU 8)CEL8 ORF8CEL 9)CEL9 ORF9CEL 10)CEL7 ORF7CEL 11)CAT4 CAT4HSA 12)BSU1 ORF1BSU 13)YFNA YFNABSU 14)MTU1 ORF1MTU 15)ORSC ORF1SCO 16)ROCE ROCEMTU 17)AAT1 AAT1ATH 18)ORFA ORF1ATH ---- Alignment ---- *** (gap penalty = 6) *** CT1M M L W Q A L R R F G CT3R M L W Q A L R R F G CT1R M G C K N L L S L G CT1H M G C K V L L N I G ERRM M G C K N L L G L G CT2M M I P C R A V L T F A CT2H M I P C R A A L T F A CEL8 M K V H Q I A CEL7 M C F S A L R CEL9 M V S H V W BSU1 M K YFNA M M MTU1 M A G ORSC M S CAT4 M A R G L P T I A S L A R L C ROCE M P T T S M S L R AAT1 ORFA M E G E E R G Y W R W S K R D F F P E E S F Q S F G S Y R A A L S Q T CT1M Q K L V R R R V L E L G M G E T R L A R C L S T CT3R Q K L V R R R L L E L G M G E T R L A R C L S T CT1R Q Q M L R R K V V D C S R E E S R L S R C L N T CT1H Q Q M L R R K V V D C S R E E T R L S R C L N T ERRM Q Q M L R R K V V D C S R E E S R L S R C L N T CT2M R C L I R R K I V T L D S L E D S K L C R C L T T CT2H R C L I R R K I V T L D S L E D T K L C R C L S T CEL8 D V L F R K K T F D G G S H L E S Q M K R C L T I CEL7 E R V F R L K N L P A G E I A T P L R R C L S T CEL9 Q A I T R K K R F E G D S H L D S N L R R C L G L BSU1 G S V F R K K S I Q D L I A A T S G E K S L K R E L G A YFNA S S L F R K K P L E T L S A Q S K S K S L A R T L S A MTU1 R R R M K S V E Q S I A D T D E P T T R L R K D L T W ORSC N T L F R T K K I E Q S I R D T E E P E H A L K K S L S A CAT4 Q K L N R L K P L E D S T M E T S L R R C L S T ROCE E L M L R R R P V S G A P V A S G A S G N L K R S F G T AAT1 M K A R S G H E M K K T L T W ORFA C S R F K N R L V S R S D D E N E R F E L K K Q S E H E M K R C L T W CT1M L D L V A L G V G S T L G_A G_V Y V L A G E V A K D K A G_P_S I V I CT3R L D L V A L G V G S T L G_A G_V Y V L A G E V A K E K A G_P_S I V I CT1R Y D L V A L G V G S T L G_A G_V Y V L A G A V A R E N A G_P_A I V I CT1H F D L V A L G V G S T L G_A G_V Y V L A G A V A R E N A G_P_A I V I ERRM F D L V A L G V G S T L G_A G_V Y V L A G A V A R E D A G_P_A I V I CT2M V D L I A L G V G S T L G_A G_V Y V L A G E V A K A D S G_P_S I V V CT2H M D L I A L G V G S T L G_A G_V Y V L A G E V A K A D S G_P_S I V V CEL8 L D V M F I A I G H M I G_A G_I Y V L T G S V V R N Q A G_P_A I I L CEL7 F D I T L L G V G H M I G_A G_I Y V L T G S V V R N T A G_P_S I I L CEL9 M D I T F L A L G Q M M G_A G_I Y V L T G T V V R N Q A G_P_S I I F BSU1 F D L T L L G I G A I I G_T G_I F V L T G T G A V T A G_P_G L T I YFNA F D L T L L G I G C V I G_T G_I F V I T G T V A A T G A G_P_A L I I MTU1 W D L V V F G V S V V I G_A G_I F T V T A S T A G D I T G_P_A I W I ORSC L D L T V F G I G V V I G_T G_I F V L T G T V A K D N A G_P_A T A L CAT4 L D L T L L G V G G M V G_S G_L Y V L T G A V A K E V A G_P_A V L L ROCE F Q L T M F G V G A T I G_T G_I F F V L A Q A V P E A G_P_G V I V AAT1 W D L M W F G I G A V I G_S G_I F V L T G L E A R N H S G_P_A V V L ORFA W D L V W F G F G S V I G_A G_I F V L T G Q E A H E Q A G_P_A I V L CT1M C F L V A A L S S V L A G L C Y_A E_F G A R V P_G S G_S A Y L Y S Y V CT3R C F L V A A L S S V L A G L C Y_A E_F G A R V P_G S G_S A Y L Y S Y V CT1R S F L I A A L A S V L A G L C Y_G E_F G A R V P_K T G_S A Y L Y S Y V CT1H S F L I A A L A S V L A G L C Y_G E_F G A R V P_K T G_S A Y L Y S Y V ERRM S F L I A A L A S V L A G P C Y_G E_F G A R V P_K T G_S A Y L Y R Y V CT2M S F L I A A L A S V M A G L C Y_A E_F G A R V P_K T G_S A Y L Y T Y V CT2H S F L I A A L A S V M A G L C Y_A E_F G A R V P_K T G_S A Y L Y T Y V CEL8 S F I F S G F A A L L S A F S Y_A E_F G A R F P_R A G_S A Y T Y S Y V CEL7 S F L L A G F A S L L S A L C Y_A E_F G A R F P_K A G_S A Y T Y T Y V CEL9 S F A L A G I A A L L S A F S Y_A E_F G A R F P_R A G_S A Y T Y T Y I BSU1 S F V V A A L A C L F A A L S Y_A E_F A S S V P_V S G_S V Y T F T Y A YFNA S F I L A G L A C A L A A F C Y_A E_F S S S I P_I S G_S V Y S Y S Y V MTU1 S F L I A A A T C A L A A L C Y_A E_F A S T L P_V A G_S A Y T F S Y A ORSC A F V V A G V V C A L A A L C Y_A E_F A S S V P_V A G_S A Y T F S Y A CAT4 S F G V A A V A S L L A A L C Y_A E_F G A R V P_R T G_S A Y L F T Y V ROCE S F I I A G I A A G L A A I C Y_A E_L A S A V P_I S G_S A Y S Y A Y T AAT1 S Y V V S G V S A M L S V F C Y_T E_F A V E I P_V A G_G S F A Y L R V ORFA S Y V V S G L S A M L S V F C Y_T E_F A V E I P_V A G_G S F A Y L R I CT1M T V G_E L W A_F T T G W N L I L_S Y V I G T A S V_A R A W_S S A F D N CT3R T V G_E L W A_F T T G W N L I L_S Y V I G T A S V_A R A W_S S A F D N CT1R T V G_E L W A_F I T G W N L I L_S Y I I G T S S V_A R A W_S A T F D E CT1H T V G_E L W A_F I T G W N L I L_S Y I I G T S S V_A R A W_S A T F D E ERRM T V G_E L W A_F I T G W D L I L_S Y I I G T S S V_P R A W_S A T F D E CT2M T V G_E L W A_F I T G W N L I L_S Y V I G T S S V_A R A W_S G T F D E CT2H T V G_E L W A_F I T G W N L I L_S Y V I G T S S V_A R A W_S G T F D E CEL8 G M G_E I W A_F I V G W T V P L_E Y M I G N A A V_A R S W_S A Y F D N CEL7 G V G_E L W A_F V I G W N I I L_E H M L G A A A V_A R S W_S G Y L D S CEL9 G F G_E L W A_F I V G W T I P L_E Y M I G N A A V_A R S W_S A Y F D N BSU1 T L G_E L M A_F I I G W D L I L_E Y M L A V S A V_S V G W_S G Y F Q S YFNA T L G_E L L A_F L I G W D L M L_E Y V I A L S A V_A T G W_S S Y F Q S MTU1 T F G_E F L A_W V I G W N L V L_E L A M G A A V V_A K G W_S S Y L G T ORSC S L G_E L P A_W I I G W D L V L_E F A L G T A V V_A V G W_S G Y I R S CAT4 S M G_E L W A_F L I G W N V L L_E Y I I G G A A V_A R A W_S G Y L D S ROCE T L G_E A V A_M V V A A C L L L_E Y G V A T A A V_A V G W_S G Y V N K AAT1 E L G_D F M A_F I A A G N I I L_E Y V V G G A A V_A R S W_T S Y F A T ORFA E L G_D F A A_F I T A G N I L L_E S I V G T A A V_A R A W_T S Y F A T CT1M L I G N H I S R T L K G T I L L K M P H V L A E Y P D F F A L CT3R L I G N H I S Q T L K G T I L L N M P H V L A E Y P D F F A L CT1R L I G K P I G E F S R Q H M A L N A P G V L A Q T P D I F A V CT1H L I G R P I G E F S R T H M T L N A P G V L A E N P D I F A V ERRM L I A K P I G E F S R K H M A L N A P G V L A P N P D I L A V CT2M L L N K Q I G Q F F K T Y F K M N Y T G L A E Y P D F F A V CT2H L L S K Q I G Q F L R T Y F R M N Y T G L A E Y P D F F A V CEL8 L V S K S V S N W T L D T V G R L S D G K G F F A L Y P D F L A F CEL7 L L G N V I S N S T I A R T G H L H E A S S F F G D Y P D L L A F CEL9 M L D N Y I K N T T I G A L G E L S E P G G F F S T Y P D I L S F BSU1 F L S G L G I H L P V A L T A A P G A V K G T F T L F N L P A F YFNA L L A G F N L H I P A A L T G A P G S M A G A V F N L P A A MTU1 V F G F G N G T G H L G S L Q L D W G A L ORSC L M D N A G W H M P A E L G G R D G A E G F G F D I L A A CAT4 M F S H S I R N F T E D P R G F L A G A P P G P L P G L P G C W H H ROCE L L S N L F G F Q M P H V L S A A P W D T H P G W V N L P A V AAT1 L L N H K P E D F R I I V H K L G E D Y S H L D P I A V ORFA L L N R S P N A L R I K T D L S S G F N L L D P I A V CT1M A L V L L L T G L L V L G A S K S A L V T K V F T G M N L L V L S F V CT3R A L V L L L T G L L V L G A N E S G L V T K V F T G M N L L V L G F V CT1R I I I I I L T G L L T L G V K E S A M V N K I F T C I N V L V L C F I CT1H I I I L I L T G L L T L G V K E S A M V N K I F T C I N V L V L G F I ERRM I I I L I L T G L L T L G V K E S A M V N K I F T C I N V L V L C F I CT2M C L V L L L A G L L S F G V K E S A W V N K F F T A I N I L V L L F V CT2H C L I L L L A G L L S F G V K E S A W V N K V F T A V N I L V L L F V CEL8 F L L F L V A V A V A M G S K F S A N V N T S F V F L N L A V L A F V CEL7 L L I V L V A F F V A L G S K V S T N F N S F L T I L N I G I V V I V CEL9 L L I C L C A C V I A V G P K V S A N V N S S F V V L N I V V I F I V BSU1 V I V M A I T Y L L Y L G I K E S K R V N N I M V I L K I L V V L L F YFNA V I I L L I T A I V S R G V K E S T R F N N V I V L M K I A I I L L F MTU1 V I V T L V A T L I A L G T K L S S R F S A V V T A I K V S V V V L V ORSC A L V L V L T A V L V L G M K L S A R I T S L V V A I K V A V V L I V CAT4 P P W P L P L S P V E P A C P P W L N H T F S A I S L L V I L F I ROCE I L I G L C A L L L I R G A S E S A R V N A I M V L I K L G V L G M F AAT1 G V C A I I C V L A V V G T K G S S R F N Y I A S I I H M V V I L F V ORFA V V I A A S A T I A S I S T R K T S L L N W I A S A I N T L V I F F V CT1M I I S G F I K G E L R N W K L T K E D Y C L T M S E S CT3R I I S G F I K G E L R N W K L T K E D Y C L T M S E S CT1R M V S G F V K G S I E N W Q L T E N K S S P L C G N CT1H M V S G F V K G S V K N W Q L T E E D F G N T S G R L C L N ERRM M V S G F V K G S I K N W Q L K E E D F L N R S S P L C G N CT2M M V A G F V K G N V A N W K I S E E F L K N I S A S A R E P P S E CT2H M V A G F V K G N V A N W K I S E E F L K N I S A S A R E P P S E CEL8 I I C G L T Y A D F S L W S G T Y Q D CEL7 V F Y G I T F A D F S L W S G V D E K CEL9 I V S G I C Y A D F N N W T G T T S D BSU1 I A V A A V Y V K P H N W Q YFNA I I V G I G Y V K P D N W MTU1 V V V G A F Y I R A A N Y S P F I P E P E V Q H H G G G L D ORSC I I A G A F F V K S A N Y D P F I P K S Q P V E A G G G L H CAT4 V I L G F I L A Q P H N W S ROCE M I I A F S A Y S A D H L K AAT1 I I A G F T K A D V K N Y S ORFA I I A G F I H A D T S N L T CT1M N G T C S L D S M G S G G F M P F G_L E G_I L R G A A T C F Y A F CT3R N G T C S L D S M G S G G F M P F G_L E G_I L R G A A T C F Y A F CT1R N D T N V K Y G E G G F M P F G_F S G_V L S G A A T C F Y A F CT1H N D T K E G K P G V G G F M P F G_F S G_V L S G A A T C F Y A F ERRM N D T N V K Y G E G G F M P F G_F S G_A L S G A A T C F Y A F CT2M N G T S I Y G A G G F M P Y G_F T G_T L A G A A T C F Y A F CT2H N G T S I Y G A G G F M P Y G_F T G_T L A G A A T C F Y A F CEL8 G R S K F F P Y G_I Q G_A I S G A S T C F F A F CEL7 G N S R F F P Y G_V S G_M F A G A A S C F F A Y CEL9 G R S M F F P F G_L T G_T L T G A A T C F F S Y BSU1 P F M P M G_F G G_V F S A A A L V F F A F YFNA S P F M P F G_M K G_V I L S A A T V F F A Y MTU1 Q S V F S L L T G A Q G S H Y G_W Y G_V L A G A S I V F F A F ORSC S P L I Q L M F G W A P S N F G_V M G_I F T A A S V V F F A F CAT4 A D E G G F A P F G_F S G_V M A G T A S C F Y A F ROCE D F V P F G_V A G_I G S A A G T I F F S Y AAT1 D F T P Y G_V R G_V F K S A A V L F F A Y ORFA P F L P F G_P E G_V F R A A A V V Y F A Y CT1M V G_F D C I A T T G E E_A Q N P_Q R S I P_M G I V I S M F I C F L A Y_ CT3R V G_F D C I A T T G E E_A Q N P_Q R S I P_M G I V I S L S I C F L A Y_ CT1R V G_F D C I A T T G E E_V K N P_Q K A I P_V G I V A S L L I C F I A Y_ CT1H V G_F D C I A T T G E E_V K N P_Q K A I P_V G I V A S L L I C F I A Y_ ERRM V G_F D C I A T T G E E_V K N P_Q K A I P_V G I V A S L L I C F V A Y_ CT2M V G_F D C I A T T G E E_V R N P_Q K A I P_I G I V T S L L V C F M A Y_ CT2H V G_F D C I A T T G E E_V R N P_Q K A I P_I G I V T S L L V C F M A Y_ CEL8 I G_F E A L A T A G E E_A K N P_H R T I P_L A T F T S L A I I S V I Y_ CEL7 I G_F D G L A T A G E E_A K D P_A R S I P_I A T F S S M T I V T L S Y_ CEL9 I G_F E V L A T A G E E_V K S P_H R T I P_V A T F L S I G V I M T L Y_ BSU1 I G_F D A V S S A A E E_T K N P_A K D L P_K G I I F S L L V C T I L Y_ YFNA L G_F D A V S N A S E E_V K N P_Q K N M P_V G I I S A L A V C T V L Y_ MTU1 I G_F D I V A T M A E E_T K R P_Q R D V P_R G I L A S L G V V T L L Y_ ORSC I G_F D I V A T A A E E_T R N P_Q R D M P_R G I L G S L I I C T L L Y_ CAT4 V G_F D V I A A S S E E_A Q N P_R R S V P_L A I A I S L A I A A G A Y_ ROCE I G_L D A V S T A G D E_V K D P_Q K T M P_R A L I A A L V V V T G V Y_ AAT1 I G_F D A V S T M A E E_T K N P_G R D I P_I G L V G S M V V T T V C Y_ ORFA G G_F D S I A T M A E E_T K N P_S R D I P_I G L L G S M S I I T V I Y_ CT1M F G V S S A L T L M M P Y Y K L H P E S P L P E A F S Y V CT3R F G V S S A L T L M M P Y Y K L Q P E S P L P E A F T Y V CT1R F G V S A A L T L M M P Y F C L D T D S P L P G A F K Y R CT1H F G V S A A L T L M M P Y F C L D N N S P L P D A F K H V ERRM F G V S A A L T L M M P Y A C L D T D S P L P G A F K Y S CT2M F G V S A A L T L M M P Y Y L L D E K S P L P V A F E Y V CT2H F G V S A A L T L M M P Y Y L L D E K S P L P V A F E Y V CEL8 V L M G A S L T L M I P Y D L V D P D A A F A A A F E M K CEL7 V L M S A S L T L M I P Y N M V H P T A A F S D A F T M R CEL9 I L V S S T L T L M V P Y D Q V H T T A P F A E A F S A R BSU1 V T V S A I M T G V I P F A Q F A G V D H P V S L V L Q S A YFNA I A V S L V L T G M M P Y A K L N V G D P V S F A L K F V MTU1 V A V S V V L S G M V P Y T Q L R T V P G R G P A N L A T A F Q A N ORSC V G V S I V V T G M Q H Y T K L S V D A P L A D A F K A T CAT4 I L V S T V L T L M V P W H S L D P D S A L A D A F Y Q R ROCE V L V A L A A L G T Q P W Q D F A E Q E T A G L A I I L D N V T AAT1 C L M A V T L C L M Q P Y Q Q I D P D A P F S V A F S A V ORFA C L M A L S L S M M Q K Y T D I D P N A A Y S V A F Q S V CT1M G W E P A R Y L V A I G_S L C A L S T S L L G S M F P M P R_V M Y S M CT3R G W E P A R Y L V A I G_S L C A L S T S L L G S M F P M P R_V I Y A M CT1R G W E E A K Y A V A V G_S L C A L S T S L L G S M F P M P R_V I Y A M CT1H G W E G A K Y A V A V G_S L C A L S A S L L G S M F P M P R_V I Y A M ERRM G W E G A K Y T V A V G_S L C A L S T S L L G S M F P M P R_V I Y A M CT2M R W G P A K Y V V A A G_S L C A L S T S L L G S M F P L P R_I L F A M CT2H G W G P A K Y V V A A G_S L C A L S T S L L G S M F P L P R_I L F A M CEL8 G A T V A K I I M S V G_A L A G M L N N L V T G S F A L P R_A V Y A M CEL7 G A E F A S Y A V S V G_A L F G M T T S L V G G M F A L P R_C V F S M CEL9 G C T T V M Y I I S I G_A L I G L T N N L V T G V F A L P R_A V Y A M BSU1 G Q N W V A G I I D I G_A V L G M T T V M L V M L Y G Q T R_V M F A M YFNA G Q D A V A G I I S V G_A I I G I T T V M L A L L Y A Q V R_L T F A M MTU1 G V Y W A S G I I S V G_A L A G L T T V V M V L M L G Q C R_V L F A M ORSC G H P F F S G V I S F G_A A V G L T T V C M I L L L G Q S R_V F F A M CAT4 G Y R W A G F I V A A G_S I C A M N T V L L S L L F S L P R_I V Y A M ROCE H G E W A S T I L A A G_A V V S I F T V T L V T M Y G Q T R_I L F A M AAT1 G W D W A K Y I V A F G_A L K G M T T V L L V G A I G Q A R_Y M T H I ORFA G M K W G K Y L V A L G_A L K G M T T V L L V G A L G Q A R_Y V T H I CT1M A E D G L L F R V L A K V H S V T H I P I V A T L V S G V I A A F M A CT3R A E D G L L F R V L A R V H N G T H T P I V A T V V S G V I A A F M A CT1R A E D G L L F K F L A K I N D R T K T P I I A T V T S G A I A A V M A CT1H A E D G L L F K F L A N V N D R T K T P I I A T L A S G A V A A V M A ERRM A E D G L L F K Y L G R V N E R T T P T V I A T L T S G A I V A V M A CT2M A R D G L L F R F L A R V S K R Q S P V A A T M T A G V I S A V M A CT2H A R D G L L F R F L A R V S K R Q S P V A A T L T A G V I S A L M A CEL8 A D D G L I F G W F G V I N S K T K T P L N A T I V F T I I N A I L A CEL7 A D D G L L F S S L A S V N P K T Q V P T Q A L L I F G F L T A I I A CEL9 A D D G L I F K W L A H V T S S T K V P L N A I V I F T L L N A I I A BSU1 S R D G L V P G S L S K V H P K H K T P Y V A T W F F G T M S A L L G YFNA S R D G L L P G L F A K V H P S F K T P F R N T W L T G I V A A G I A MTU1 A R D G L V P R Q L A K T G S R G T P V R V T V L V A V L V A T T A ORSC S R D G L L P R F F S H V H P K F R T P Y R P T I L L G V I I A I V A CAT4 A A D G L F F Q V F A H V H P R T Q V P V A G T L A F G L L T A F L A ROCE G R D G L L P A R F A K V N P R T M T P V H N T V I V A I F A S T L A AAT1 A R A H M M P P W L A Q V N A K T G T P I N A T V V M L A A T A L I A ORFA A R T H M I P P I F A L V H P K T G T P I N A N L L V A I P S A L I A CT1M F L F E L T D L_V D L M S I G T_L_L A H S L V S I C V L I L R Y Q CT3R F L F E L T D L_V D L M S I G T_L_L A Y S L V S I C V L I L R Y Q CT1R F L F E L K D L_V D L M S I G T_L_L A Y S L V A A C V L V L R Y Q CT1H F L F D L K D L_V D L M S I G T_L_L A Y S L V A A C V L V L R Y Q ERRM F L F E L K D L_V D L M S I G T_L_L A Y S L V A A P V L V L K Y Q CT2M F L F D L K A L_V D M M S I G T_L_M A Y S L V A A C V L M L R Y Q CT2H F L F D L K A L_V D M M S I G T_L_M A Y S L V A A C V L I L R Y Q CEL8 L V F D L Q A L_V D F L S I G T_L_L A Y S M V S I C V I I L R H Q CEL7 L L F D I T T L_V E F L S I G T_L_L A Y S I V S A C V I V L R Y Q CEL9 L I F D I E A L_V E F L S I G T_L_F A Y S F V S G S V L V L R Y Q BSU1 S L V P L D E L_A K L V N I G T_L_S A F V L I S V A V I V L R K YFNA G F I N L G T L_A H L V N M G T_L_A A F T V I S I A V I V L R K MTU1 S V F P I T K L_E E M V N V G T_L_F A F I L V S A G V V V L R R ORSC G F T S L S E L_A E L V N I G T_L_F A F V V V A I S V I I L R R CAT4 L L L D L E S L_V Q F L S L G T_L_L A Y T F V A T S I I V L R F Q K S ROCE A F I P L D S L_A D M V S I G T_L_T A F S V V A V G V I V L R V AAT1 F F T K L K I L_A D L L S V S T_L_F I F M F V A V A L L V R R Y Y ORFA F F S G L D V L_A S L L S I S T_L_F I F T M M P I A L L V R R Y Y CT1M P D Q E M K S V E E E M E L Q E E T CT3R P D Q E M K N G E E E V E L Q E E R T CT1R P E Q P N L V Y Q M A R T T D E L D Q V D Q N E M V S A S E S Q T CT1H P E Q P N L V Y Q M A S T S D E L D P A D Q N E L A S T N D S Q L ERRM P E Q P N L V Y Q M A R T T D E L D H V D Q N E L V S A S D S Q T CT2M P G L C Y E Q P K Y T P E K E T L E S C T N A T L K S E S Q V CT2H P G L S Y D Q P K C S P E K D G L G S S P R V T S K S E S Q V CEL8 S H L V D G S A T D Y D N G G C L K S W V CEL7 P A Y N V D E G Q F D N G G K L R F S I CEL9 S A P I D G D G K R M D N G G E L S S W I BSU1 YFNA MTU1 ORSC CAT4 S P P S S P G P A S P G P L T K Q Q S S F S D H L Q L V G T V H A S V ROCE AAT1 V T G E T S T R ORFA V R Q D T CT1M L E A E K L T V Q A L F C P V N S I P T L L S G R V V Y V C S CT3R L E A E K L T V Q A L F C Q V D S I P T L L S G R I V Y V C S CT1R G F L P A A E K F S L K T I L S P K N M E P S K F S G L I V N I S A CT1H G F L P E A E M F S L K T I L S P K N M E P S K I S G L I V N I S T ERRM G F L P V T E N F S L K S K L S P K N M E P T Q F S G L I V N C S T CT2M T M L Q G Q G F S L R T L F S P S A L P T R Q S A S L V S F L V CT2H T M L Q R Q G F S M R T L F C P S L L P T Q Q S A S L V S F L V CEL8 P F Q G V W E N F S E G I S I R V A CEL7 P F C G F L D K L Q P G H S I Y Y G M S V M I A S CEL9 P A R N F W E S L P A G T S I S L G BSU1 YFNA MTU1 ORSC CAT4 P E P G E L K P A L R P Y L G F L D G Y S P G A V V T W A L ROCE AAT1 D R N K F L V ORFA P R V H L I K L I T CT1M S L L A V L L T V L C L V L T W W T T P L R S G D P V W V T V V V L CT3R S L L A V L L T V L C L V L T W W T T P L H S G D P V W V T V V V L CT1R G L L A V L I I T V C I V A V L G R E A L A E G T L W A V F V M T G CT1H S L I A V L I I T F C I V T V L G R E A L T K G A L W A V F L L A G ERRM T L L T N L I I I V C I V A V L P R E P L A E G T L W A V F V M T G CT2M G F L A F L I L G L S I L T T Y G V Q A I A R L E A W S L A L L A CT2H G F L A F L V L G L S V L T T Y G V H A I T R L E A W S L A L L T CEL8 V A G L I F G Y I C L A I P F R T G I F S N A G G I I L L T V G CEL7 M F F S G L G F S S G Y L Y G T V L C Q I F L L V N CEL9 V A A L I G S F F W L A F T F R T G F Y E H W Y G Q I S I G BSU1 YFNA MTU1 ORSC CAT4 G V M L A S A I T I G C V L V F G N S T L H L P H W G Y I L L L L L T ROCE AAT1 F L G L I L A S S T A T A V Y W A L E E E G W I G Y C I T V ORFA C L L F V V V S S M G T S A Y W G M Q R K G S W I G Y T V T V CT1M I L G L I L A I S G V I W R Q P Q N R T P L H F K V P_A V P_L L P_L CT3R I L G L I L G I S G V I W R Q P Q N R T P L H F K V P_V V P_L L P_L CT1R S V L L C M L V T G I I W R Q P E S K T K L S F K V P_F V P_V L P_V CT1H S A L L C A V V T G V I W R Q P E S K T K L S F K V P_F L P_V L P_I ERRM S V L L C M L V T G I I W R Q P E S K T K L T F K V P_F V P_V L P_I CT2M L F L V L C A A V I L T I W R Q P Q N Q Q K V A F M V P_F L P_F L P_A CT2H L F L V L F V A I V L T I W R Q P Q N Q Q K V A F M V P_F L P_F L P_A CEL8 A A F S L L S F V F I L G H E Q N K S T S T Y K V P_L V P_F I P_C CEL7 I A L I I L S F L F I C A H Y P N N T P L D F K V P_L V P_L I P_A CEL9 F N G L L I V L V M A F I L G H Q Q N S L E T S F K V P_F V P_F L P_C BSU1 K Q P D L P R A F K C P_G V P_V I P_G YFNA K H P E I K A S F R V P_F V P_V V P_I MTU1 T R P D L Q R G F T A P_W V P_L L P_I ORSC T R P D L P R A F R T P_L V P_L L P_I CAT4 S V M F L L S L L V L G A H Q Q Q Y R E D L F Q I P_M V P_L I P_A ROCE R E P D L P R G F K V P_G Y P_V T P_V AAT1 P I W F L S T V A M K F L V P Q A R A P K I W G V P_L V P_W L P_S ORFA P F W F L G T L G I V F F V P Q Q R T P K V W G V P_L V P_W L P_C CT1M V S I F V N V Y L M M Q M T A G T W A R F G I W M L I G F A I Y_F G Y CT3R V S I F V N V Y L M M Q M T A D T W A R F G V W M L I G F A I Y_F G Y CT1R L S I F V N I Y L M M Q L D Q G T W V R F A V W M L I G F A I Y_F G Y CT1H L S I F V N V Y L M M Q L D Q G T W V R F A V W M L I G F I I Y_F G Y ERRM L S I F V N V Y L M M Q L D Q G T W V R F A V W M L I G F S I Y_F G Y CT2M F S I L V N I Y L M V Q L S A D T W I R F S I W M A L G F L I Y_F A Y CT2H F S I L V N I Y L M V Q L S A D T W V R F S I W M A I G F L I Y_F S Y CEL8 L G L L I N V F M M V Y L N S M T W I R L F V W L A I G I V I Y_I C Y CEL7 L S L L I N T L M M V H L A W I T W L R L V V W M S I G F V I Y_F G Y CEL9 L S L L V N V F M M A Y L T T A T W I R L F V W M G V G L L I Y_F S Y BSU1 L A I L F C L F L I L N L G W V T I V R F L V W L L I G L V I Y_F L Y YFNA I S A G I C L W F M Y S L P G V T W L S F V I W I A V G T L V Y_F L Y MTU1 A A V C A C L W L M L N L T A L T W I R F G I W L V A G T A I Y_V G Y ORSC V S V A A S L W L M L N L P A E T W V R F A I W M A I G F V V Y_F L Y CAT4 L S I V L N I C L M L K L S Y L T W V R F S I W L L M G L A V Y_F G Y ROCE L S V L A C G Y I L A S L H W Y T W L A F S G W V A V A V I F Y_L M W AAT1 A S I A I N I F L L G S I D T K S F V R F A I W T G I L L I Y Y_V L F ORFA L S I A T N I F L M G S L G A M A F V R F G V C T L A M L L Y Y_F L L CT1M G I Q H_S M K E V K N H Q T L P K T R A Q CT3R G I Q H_S V E E V K N H Q T L P K T R P Q CT1R G V W H_S E E A S L A A G Q A K CT1H G L W H_S E E A S L D A D Q A R ERRM G L W H_S E E A S L A A G Q A R CT2M G I R H_S L E G N P R D E E D D E D A F S E N I N V A T E E K S V M Q CT2H G I R H_S L E G H L R D E N N E E D A Y P D N V H A A A E E K S A I Q CEL8 G I R H_S K E G Q K L S K I D V H N E I M S R CEL7 G I H H_S K E E V Q D A E K F S K S S CEL9 G I R H_S K E A K K L T T I A D I R M S S BSU1 S R K H_S K YFNA S R K H_S L MTU1 G R R H_S A Q G L R Q A R ORSC G R T H_S R L A R G E E A P CAT4 G I R H_S K E N Q R E L P G L N S T H Y V V F P R G S L E E T V Q A M ROCE G R H H_S A L N E E AAT1 G L H_A T Y D T A K A T L K E K Q A L Q K A E ORFA G L H_A T F D M A H Q Q CT1M T I D L D L T T S C V H S I CT3R T I D L D L T T S C V H S I CT1R T P D S N L D Q C K CT1H T P D G N L D Q C K ERRM T P D S N L D Q C K CT2M A N D H H Q R N L S L P F I L H E K T S E C CT2H A N D H H P R N L S S P F I F H E K T S E F CEL8 T S D T K V H CEL7 T Y E S V V S G V V A G A G T T S P CEL9 T F P N K N N R I T K T BSU1 L N Q YFNA L N K MTU1 E S A T R R C ORSC A D P A E P S G T CAT4 Q P P S Q A P A Q D P G H M E ROCE V P AAT1 E G G V V A D N S C S A T ORFA I V P R T -- Results -- Length of sequences with gaps = 726 Average sequence length: 574 Percent identity (based on aligned regions): CT1M CT3R CT1R CT1H ERRM CT2M CT2H CEL8 CEL7 CEL9 BSU1 YFNA MTU1 ORSC CAT4 ROCE AAT1 ORFA CT1M 0.00 94.50 61.26 60.73 59.01 56.69 57.85 36.88 42.08 38.31 34.79 36.70 37.58 39.38 40.78 31.53 31.98 33.02 CT3R 94.50 0.00 61.98 61.45 59.57 57.43 58.58 37.52 41.83 38.25 35.45 37.14 37.37 39.18 40.72 32.18 31.73 33.52 CT1R 61.26 61.98 0.00 88.30 90.38 61.17 60.69 38.27 40.35 39.30 39.47 39.21 38.19 37.06 41.61 37.15 33.46 32.07 CT1H 60.73 61.45 88.30 0.00 85.19 61.10 60.94 38.56 41.16 38.70 38.82 39.43 37.79 36.55 41.28 36.50 32.68 31.69 ERRM 59.01 59.57 90.38 85.19 0.00 59.48 59.32 38.20 38.70 38.18 38.60 38.55 36.19 36.14 39.93 35.64 32.10 30.93 CT2M 56.69 57.43 61.17 61.10 59.48 0.00 90.56 37.39 39.69 37.72 35.96 37.44 37.92 36.33 37.89 34.77 31.69 29.94 CT2H 57.85 58.58 60.69 60.94 59.32 90.56 0.00 37.39 40.38 38.58 37.06 38.11 37.50 37.35 38.54 34.99 32.26 30.70 CEL8 36.88 37.52 38.27 38.56 38.20 37.39 37.39 0.00 53.01 59.15 35.23 35.82 33.48 34.89 37.61 30.95 32.50 32.63 CEL7 42.08 41.83 40.35 41.16 38.70 39.69 40.38 53.01 0.00 51.59 38.07 38.02 38.39 37.97 41.26 32.68 31.98 31.47 CEL9 38.31 38.25 39.30 38.70 38.18 37.72 38.58 59.15 51.59 0.00 35.00 38.21 36.07 34.86 36.30 31.32 32.18 30.84 BSU1 34.79 35.45 39.47 38.82 38.60 35.96 37.06 35.23 38.07 35.00 0.00 55.56 43.72 49.67 36.54 42.20 35.37 32.89 YFNA 36.70 37.14 39.21 39.43 38.55 37.44 38.11 35.82 38.02 38.21 55.56 0.00 41.86 49.45 36.92 42.22 34.47 33.78 MTU1 37.58 37.37 38.19 37.79 36.19 37.92 37.50 33.48 38.39 36.07 43.72 41.86 0.00 53.35 35.95 36.53 35.52 32.60 ORSC 39.38 39.18 37.06 36.55 36.14 36.33 37.35 34.89 37.97 34.86 49.67 49.45 53.35 0.00 37.08 37.99 36.64 35.28 CAT4 40.78 40.72 41.61 41.28 39.93 37.89 38.54 37.61 41.26 36.30 36.54 36.92 35.95 37.08 0.00 31.10 29.22 29.70 ROCE 31.53 32.18 37.15 36.50 35.64 34.77 34.99 30.95 32.68 31.32 42.20 42.22 36.53 37.99 31.10 0.00 32.35 29.09 AAT1 31.98 31.73 33.46 32.68 32.10 31.69 32.26 32.50 31.98 32.18 35.37 34.47 35.52 36.64 29.22 32.35 0.00 62.17 ORFA 33.02 33.52 32.07 31.69 30.93 29.94 30.70 32.63 31.47 30.84 32.89 33.78 32.60 35.28 29.70 29.09 62.17 0.00 Distance scores for phylogenetic tree: CT1M CT3R CT1R ERRM CT1H CT2M CT2H CEL8 CEL9 CEL7 CAT4 BSU1 YFNA MTU1 ORSC ROCE AAT1 ORFA CT1M 0.00 4.56 43.18 47.58 44.30 54.75 53.57 89.20 86.94 81.83 87.93 111.25 103.32 108.38 103.91 121.62 109.87 114.23 CT3R 4.56 0.00 43.06 47.57 43.81 53.96 52.80 87.77 86.85 82.82 87.90 110.97 102.37 108.04 103.64 120.02 110.00 111.97 CT1R 43.18 43.06 0.00 8.86 10.65 46.04 46.45 83.70 85.58 82.52 83.33 103.13 97.57 105.60 101.81 112.55 108.00 114.77 ERRM 47.58 47.57 8.86 0.00 14.04 49.86 49.72 86.40 89.42 87.84 88.64 106.46 101.37 108.70 104.13 116.93 112.30 119.68 CT1H 44.30 43.81 10.65 14.04 0.00 46.04 46.30 84.49 86.58 82.52 86.22 105.39 99.23 106.25 101.87 114.23 110.11 116.08 CT2M 54.75 53.96 46.04 49.86 46.04 0.00 7.55 91.53 92.83 89.28 90.98 114.64 107.40 111.76 109.21 122.90 112.22 121.50 CT2H 53.57 52.80 46.45 49.72 46.30 7.55 0.00 91.09 90.81 89.02 89.23 112.79 105.98 111.57 107.35 122.02 110.73 120.63 CEL8 89.20 87.77 83.70 86.40 84.49 91.53 91.09 0.00 43.98 56.88 91.38 107.35 102.88 113.43 110.36 119.53 102.89 112.61 CEL9 86.94 86.85 85.58 89.42 86.58 92.83 90.81 43.98 0.00 60.90 92.57 107.62 100.87 110.05 105.09 122.68 105.09 116.47 CEL7 81.83 82.82 82.52 87.84 82.52 89.28 89.02 56.88 60.90 0.00 85.91 102.44 100.27 107.44 103.46 116.01 108.08 118.15 CAT4 87.93 87.90 83.33 88.64 86.22 90.98 89.23 91.38 92.57 85.91 0.00 110.46 110.31 116.92 111.69 127.42 120.02 124.08 BSU1 111.25 110.97 103.13 106.46 105.39 114.64 112.79 107.35 107.62 102.44 110.46 0.00 44.98 77.97 63.25 73.02 108.67 115.67 YFNA 103.32 102.37 97.57 101.37 99.23 107.40 105.98 102.88 100.87 100.27 110.31 44.98 0.00 80.35 61.36 74.32 107.79 111.53 MTU1 108.38 108.04 105.60 108.70 106.25 111.76 111.57 113.43 110.05 107.44 116.92 77.97 80.35 0.00 58.65 96.11 106.76 116.37 ORSC 103.91 103.64 101.81 104.13 101.87 109.21 107.35 110.36 105.09 103.46 111.69 63.25 61.36 58.65 0.00 87.52 99.42 108.30 ROCE 121.62 120.02 112.55 116.93 114.23 122.90 122.02 119.53 122.68 116.01 127.42 73.02 74.32 96.11 87.52 0.00 114.11 122.84 AAT1 109.87 110.00 108.00 112.30 110.11 112.22 110.73 102.89 105.09 108.08 120.02 108.67 107.79 106.76 99.42 114.11 0.00 57.30 ORFA 114.23 111.97 114.77 119.68 116.08 121.50 120.63 112.61 116.47 118.15 124.08 115.67 111.53 116.37 108.30 122.84 57.30 0.00 Branching order: (CT1M,CT3R)CT1R)ERRM)CT1H)CT2M)CT2H)CEL8)CEL9)CEL7)CAT4)BSU1) YFNA)MTU1)ORSC)ROCE)AAT1)ORFA) Clusters: (CT2M,CT2H) (CT1R,ERRM)CT1H) (CEL8,CEL9)CEL7) (BSU1,YFNA)MTU1)ORSC)ROCE) (AAT1,ORFA) (MTU1,ORSC) A)CT1M CATMMU B)CT3R CAT3RNO C)CT1R CAT1RNO D)ERRM ERRMAU E)CT1H CAT1HSA F)CT2M CAT2MMU G)CT2H CAT2HSA H)CEL8 ORF8CEL I)CEL9 ORF9CEL J)CEL7 ORF7CEL K)CAT4 CAT4HSA L)BSU1 ORF1BSU M)YFNA YFNABSU N)MTU1 ORF1MTU O)ORSC ORF1SCO P)ROCE ROCEMTU Q)AAT1 AAT1ATH R)ORFA ORF1ATH Branch lengths: (r1,r2,r3,r4,r5) (r6,r7,........) 2.54 2.02 21.35 2.47 6.39 2.19 5.72 14.97 0.35 4.24 3.31 23.60 19.88 21.71 22.27 8.77 28.13 13.39 -3.17 47.92 14.71 24.50 20.49 11.62 32.55 26.10 7.29 -0.17 47.55 15.74 29.09 24.94 32.36 % s.d. (observed vs calculated) = 2.99