Relevant Publications

Elson D, Ryan H, Johnson R, and Arbeit JM. (2000) Coordinate Upregulation Of HIF-1a And HIF-1 Target Genes During Multistage Epidermal Carcinogenesis And Wound Healing. Cancer Research 60:6189-6195

Elson DA, Thurston G, Huang LE, Ginzinger DG, McDonald DM, Johnson RS, and Arbeit JM.  (2001) Induction of hypervascularity without leak or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1a.  Genes and Development 15:2520-2532.

Cramer T, Yamanishi Y, Clausen BE, Förster I, Pawlinski R, Mackman N, Haase V, Jaenisch R, Corr M, Nizet V, Firestein GS, Gerber H, Ferrara N, and Johnson RS. (2003) HIF-1a is essential for myeloid cell-mediated inflammation. Cell 112:645-657

Cramer T and Johnson RS.  (2003) A novel role for the hypoxia inducible transcription factor HIF-1a: regulation of inflammation.  Cell Cycle 2:3 192-193

Peyssonnaux C and Johnson RS.  (2004) An unexpected role for hypoxic response.
Cell Cycle 3(2):168-171

Peyssonnaux C, Cramer T, Datta V, Haase V, Theodorakis E, Nizet V, and Johnson RS. (2005) HIF-1alpha expression regulates the bactericidal capacity of phagocytes. Journal of Clinical Investigation 115(7):1806-15

Walmsley S, Print C, Farahi N, Peyssonnaux C, Johnson RS, Cramer T, Sobolewski A, Condliffe A, Cowburn AS, Johnson N, and Chilvers ER. (2005) Hypoxia-induced neutrophil survival is mediated by HIF-1–dependent NF-B activity Journal of Experimental Medicine 201:105-115

Neumann AK, Yang J, Biju MP, Joseph SK, Johnson RS, Haase VH, Freedman BD, Turka LA. (2005) Hypoxia inducible factor-1 alpha regulates T cell receptor signal transduction.Proceedings of the National Academy of Sciences 102:17071-17076

Peyssonnaux C, Zinkernagel AS, Datta V, Lauth X, Johnson RS and Nizet V.
(2006) TLR-4 dependent hepcidin expression by myeloid cells in response to bacterial pathogens. Blood 107:3727-3732

Peyssonnaux C, Zinkernagel AS, Schuepbach RA, Rankin E, Vaulont S, Haase VH, Nizet V, and Johnson RS. (2007) Regulation of iron homeostasis by the hypoxia inducible transcription factors (HIF).Journal of Clinical Investigation  117:1926-1932

Peyssonnaux C, Cejudo-Martin P, Doedens A, Zinkernagel A, Johnson RS, and Nizet V. (2007) Essential Role of Hypoxia Inducible Factor-1α in Development of LPS-Induced Sepsis. Journal of Immunology 178:7516-7519

Peyssonnaux C, Nizet V, and Johnson RS. (2008) Role of the Hypoxia Inducible Factor in iron metabolism. Cell Cycle (in press)

Peyssonnaux C, Boutin AT, Zinkernagel A, Datta V, Nizet V, and Johnson RS. (2008)
Critical role of HIF-1α in keratinocyte defense against bacterial infection. Journal of Investigative Dermatology (in press)

Zinkernagel AS, Johnson RS, and Nizet V. (2008) Hypoxia inducible factor (HIF) function in innate immunity and infection. Journal of Molecular Medicine (in press)