home
| Research |
| Personnel |
| Contacts |
| San Diego |
| UCSD Biology |
Cancer One of the functions of the mammalian hypoxic response in development and cancer is the generation of nascent vascular networks through angiogenesis. Through transcriptional regulation of the vascular endothelial growth factor A (VEGF-A) and other angiogenic factors, the Hypoxia-Inducible Factor 1 and 2 alpha (HIF-1alpha and HIF-2alpha) can increase angiogenesis in an oxygen dependent fashion, giving a survival and growth advantage to HIF wild type tumors. We use genetic techniques to study the role of these pathways in cancer and other pathologies. |
Relevant Publications: Ryan H, Lo J, and Johnson RS. (1998) The hypoxia inducible factor-1a gene is required for embryogenesis and solid tumor formation. EMBO Journal 17:3005-3015 Grunstein J, Roberts WG, Mathieu-Costello O, Hanahan D, and Johnson RS. (1999) Salnikow S, Blagosklonny M, Ryan H, Johnson R, and Costa M. (2000) Nickel induces hypoxia genes. Cancer Research 60:38-41 Garayoa M, Martinez, A, Lee S, Pio R, An W, Neckers L, Trepel J, Montuenga L, Miller M, Ryan H, Johnson RS, Gassmann M, and Cuttitta F. (2000) Hypoxia inducible factor-1 upregulates adrenomedullin expression in human tumor cell lines during oxygen deprivation. Molecular Endocrinology 14:848-862 Grunstein J, Masbad J, Hickey R, Giordano F, and Johnson RS. (2000) Isoforms of Vascular Endothelial Growth Factor act in a coordinate fashion to recruit and expand vascular beds: a model for tumor-induced signaling to the vasculature. Ryan H, Poloni M, McNulty W, Gassmann M, and Johnson RS. (2000) Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth. Cancer Research 60:4010-4015 Giordano F and Johnson RS. (2001) Angiogenesis: the role of the microenvironment in flipping the switch. Current Opinion in Genetics and Development 11:35-40 Seagroves T, and Johnson RS. (2002) Two HIFs may be better than one. Cancer Cell 1:211-213 Gupta VK, Jaskowiak NT, Beckett MA, Mauceri HJ, Grunstein J, Johnson RS, Calvin DA, Nodzenski E, Pejovic M, Kufe DW, Posner MC, Weichselbaum RR. (2002) Unruh A, Katschinski DM, Mohamed HG, Johnson RS, Nadrowitz R, Richter E, and Wenger RH. (2003) The hypoxia-inducible factor-1a is a negative factor for tumor therapy. Oncogene 22:3213-3220 Goda N, Dozier SJ, and Johnson RS. (2003) HIF-1 in cell cycle regulation, apoptosis, and tumor progression. Antioxidants and Redox Signaling 5:467-473 Blouw B, Song H, Bosze J, Tihan T, Johnson RS, and Bergers G. (2003) The hypoxic response of tumors is dependent on their microenvironment. Cancer Cell 4:133-146 Tang N, Wang L, Esko J, Giordano FJ, Huang Y, Gerber HP, Ferrara N, and Johnson RS. (2004) Loss of HIF-1a in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 6:485-495 Poellinger L, and Johnson RS. (2004) HIF-1 and hypoxic response: The plot thickens Kaufman B, Scharf O, Arbeit J, Ashcroft M, Brown JM, Bruick RK, Chapman JD, Evans SM, Giaccia AJ, Huang LE, Johnson R, Kaelin W.Jr, Koch CJ, Maxwell P, Mitchell J, Neckers L, Powis G, Rajendran J, Semenza GL, Simon J, Storkebaum E, Welch MJ, Whitelaw M, Melillo G, and Ivy SP (2004) Proceedings of the Oxygen Homeostasis/Hypoxia Meeting. Cancer Research 64:3350-3356. Liao D, Corle C, Seagroves TN, and Johnson RS. (2007) HIF-1α is a key regulator of metastasis in a transgenic model of cancer initiation and progression. Cancer Research 67:563-572 Blouw B, Haase VH, Song H, Bergers G, and Johnson RS. (2007) Loss of VEGF expression reduces vascularization, but not growth, of tumors lacking the Von Hippel-Lindau tumor suppressor gene. Oncogene 26:4531-4540 Liao D and Johnson RS. (2007) Hypoxia: A key regulator of angiogenesis in cancer.
|