UC San Diego SearchMenu

Jeffrey Long

Jeffrey Long

Assistant Adjunct Professor
Section of Cell and Developmental Biology, UCSD
Plant Molecular and Cellular Biology Laboratory,
The Salk Institute

e-mail: long@salk.edu
Salk Institute Web Page

      My laboratory is currently dissecting several pathways that relate to early embryonic decisions in plants.  We work on several pathways that regulate the specification and maintenance of the embryonic stem cell populations of the shoot and the root.  We are also trying to uncover the molecules and mechanisms that specify embryonic and lateral organ polarity.  We use a combination of genetics, genomics, biochemistry, and microscopy to address these questions and have uncovered several transcriptional cascades necessary for proper plant development.  We have also found that several chromatin modifying enzymes play key roles in plant development and are attempting to tease apart their specific functions.

figure 1

Long, J., Ohno, C., Smith, Z., and Meyerowitz, E. (2006)  TOPLESS regulates apical embryonic fate in Arabidopsis.  Science 312: 1520-1530.

Szemenyei, H., Hannon, M. and Long, J. (2008) TOPLESS mediates auxin dependent transcriptional repression during Arabidopsis embryogenesis.  Science 319: 1384-1386.

Smith, Z.R. and Long, J.A. (2010) Control of Arabidopsis apical-basal embryo polarity by two antagonistic transcription factor families.  Nature 464(7287): 423-426. 

Pauwels, L., Barbero, G.F., Geerinck, J., Tilleman, S., Grunewald, W., Perez, A.C., Chico, J.M., Vanden Bossche, R., Sewell, J., Gil, E., Garcia-Casado, G., Witters, E., Inze, D., Long, J.A., De Jaeger, G., Solano, R. and Goossens, A. (2010) NINJA connects JAZ proteins to the co-repressor TOPLESS.  Nature 464: 788-791.

Wollmann H, Mica E, Todesco M, Long JA, Weigel D. (2010) On reconciling the interactions between APETALA2, miR172 and AGAMOUS with the ABC model of flower development.  Development 137(21): 3633-3642.