| M W F; 10:10 - 11:00 pm |
Molecular Biology |
Douglas W. Smith |
| York 2722 |
BIMM 100 |
5254 Muir Biology Building |
| Fall, 2000 |
x42620; dsmith@ucsd.edu |
| BIMM100 | Syllabus
| Sections / Off Hrs | Grading
Policy | DNASYSTEM
|
| Lectures | Journal
Articles | Study Qs | Lab
Techniques | Exams |
The following links are to Lecture Notes for BIMM 100, Fall, 2000.
The Lecture Notes below on the Web are those modified throughout the Fall 2000 course, to reflect the shift in emphasis from a Genes oriented course to a Genome oriented course
NOTE: The designation of which Topics are covered in a given Lecture is only approximate. Due to a variety of circumstances, a particular Topic may be covered in a Lecture different from that shown below, or in some cases may not explicitly be covered in Lecture.
You are still responsible for material in the Lecture Notes even if not covered explicitly in lecture.
When Lecture Notes for Fall, 2000, are made available, there will be a link below to those Lecture Notes.
|
Lecture |
Date |
Topic |
|
1 |
F 22 Sep |
Mol
Biol; Genomes Mol Biol; Genetic Material; Nucleic Acid Structure; Genes |
|
2 |
M 25 Sep |
Genome
Mapping: Physical - Low Resolution R. enzymes; Modification; Gels; Hybridization; Restriction Maps; DNA Chips |
|
3 |
W 27 Sep |
Genome
Mapping: Cloning - High Resolution Cloning; Vectors; Reverse Genetics; Libraries; ESTs; Rad Hybrids; STSs |
|
4 |
F 29 Sep |
Genome
Mapping: Genetic Physical / Genetic Maps; DNA Markers (RFLPs, SSLPs, SNPs); PCR; Pedigree |
|
5 |
M 2 Oct |
Genome
Sequencing Chemical / Dideoxy; Automated; Genome Assembly; Shotgun; Clones; Markers |
|
6 |
W 4 Oct |
Functional
Genomics: Basics Genome Element (Genes / Sites) Location and Function; Computational / Expt |
|
7 |
F 6 Oct |
Genome
Anatomies: Prokaryotic DNA Supercoils, Topos; Bacterial Nucleoid; Packing Ratio; Mito DNA |
|
8 |
M 9 Oct |
Genome
Anatomies: Eukaryotic Chromatin; Nucleosomes; 30 nm Fiber; MARs, SARs |
|
9 |
W 11 Oct |
Genome
Anatomies: Mobile Elements Prok IS, Tns; Transposition; Euk Tns; Retrotransposons; LINEs, SINEs |
|
10 |
F 13 Oct |
Genome Function: DNA-binding
Proteins This material will be incorporated within other lectures |
|
11 |
M 16 Oct |
Genome
Duplication: DNA replication - Basics Principles, Meselson-Stahl, SemiDiscontinuous Synthesis; Polymerases |
|
12 |
W 18 Oct |
Genome
Duplication: DNA replication - Initiation and Elongation Elongation Process, Proteins, Euk vs Prok, Replication Origins |
|
13 |
F 20 Oct |
Genome
Duplication: DNA replication - Termination Prokaryotic Termination; Telomeres; Telomerase |
|
14 |
M 23 Oct |
Genome Evolution: Mutations This material is review material from Genetics, with some in DNA Repair lec |
|
15 |
W 25 Oct |
Genome
Evolution: DNA Repair Mutations; Direct Repair; Nucleotide Excision; Base Excision; Mismatch; SOS |
|
16 |
F 27 Oct |
Genome
Evolution: Homologous Recombination Breakage-Reunion; Meselson-Radding; Enzymes; Gene Conversion |
|
17 |
M 30 Oct |
Genome
Function: Prokaryotic RNA Transcription RNA pol; Sigmasss; Promoters; DNA footprinting; Elongation; Termination |
|
18 |
W 1 Nov |
Genome
Function: Prokaryotic Transcription Regulation Operon Theory: Catabolite (Lac), Anabolic (Trp); Genetics; CAP; Attenuation |
|
19 |
F 3 Nov |
Genome
Function: Eukaryotic RNA Transcription Basics; RNA pols I, II, III; Methodologies |
|
20 |
M 6 Nov |
Genome
Function: Eukaryotic Transcription Regulation Sites, Proximal, Enhancers; Response Elements; Transcrip Factors; Two Hybrid |
|
21 |
W 8 Nov |
Genome
Function: RNA Processing hnRNA; G Cap; poly(A); Splicing; Editing |
|
22 |
M 13 Nov |
Genome
Function: RNA Splicing GU-AG; Spliceosomes; snRNPs; RNaseP; Ribozymes; L-19 RNA |
|
23 |
W 15 Nov |
Genome Function: Total
Expression This material will be incorporated within other lectures |
|
24 |
F 17 Nov |
Proteome
Synthesis: Genetic Codes Basics; Crick T4 expt; Codons IDs; NonUniversality |
|
25 |
M 20 Nov |
Proteome
Synthesis: tRNA, Ribosomes Translation Basics; tRNA: Adaptor, Structure, Function, Wobble; Ribosomes |
|
26 |
W 22 Nov |
Proteome
Synthesis: Translation and Processing Initiation, Prok vs Euk; Elongation; Termination; Nonsense Suppressors |
|
27 |
M 27 Nov |
PostGenome
Molecular Biology and Genome
Evolution Lander 10 Goals; RNA World; Genome Duplication; Gene Duplication |
|
28 |
W 29 Nov |
Genome
Evolution: Phylogenetics Multiple Sequence Alignments; Trees; Bootstrapping; Human Prehistory |
|
29 |
F 1 Dec |
Bioinformatics:
Databases and Software Tools Bioinformatics, Software, Sequence Databases, Organism Databases |
| BIMM100 | Syllabus
| Sections / Off Hrs | Grading
Policy | DNASYSTEM
|
| Lectures | Journal
Articles | Study Qs | Lab
Techniques | Exams |
If you have problems or comments, send email to Doug Smith