BILD 1			                    Dr. Nigel Crawford
Winter 1997			            Due:  Jan. 28, 1997
PROBLEM SET #2

1.  Where is RNA made in the cell?  Name the four monomers that 
make up RNA.  What part of the monomer provides the chemical 
energy to form the linkages that make up the RNA polymer?

2.  Where are ribosomes made in the cell?  What are ribosomes made 
of (two components)?  Where are ribosomes located in the cell? 

3.  Is DNA synthesis an endergonic or exergonic reaction?  Is ÆS 
positive or negative?  dGTP is required for DNA synthesis; what role 
might this molecule play?

4.  Identify four features that all cells have in common and three 
differences between prokaryotes and eukaryotes.

5.  How does the endosymbiosis theory explain the origin of (1) 
mitochondria and (2) ribosomes?  Give two pieces of evidence that 
supports your explanation for each organelle.

6.  When KOH is dissolved in water, the solution becomes hot.  When 
CsCl is dissolved in water, the solution becomes cold.  Indicate for 
each reaction whether it is exergonic or endergonic and what are the 
signs for ÆG, ÆH and ÆS (ie. + or -).

7.  Sucrose synthase is an enzyme that will combine glucose and 
fructose to produce sucrose (a disaccharide).  For this reaction ÆG= +7 
kcal/mole.  Draw an energy diagram labeling reactants, products, 
change in Gibbs Free energy, and energy of activation.  How does 
sucrose synthase affect the Gibbs Free energy change and the energy 
of activation?

8.  For the reaction ATP + UDP ® ADP + UTP, a phosphate is 
transferred from ATP to UDP.  Would you expect this reaction to be 
exergonic or endergonic and would ÆG be + or -?  Draw an energy 
diagram for this reaction.

9.  How is fermentation different and how is it similar to respiration?