Spring 2000
Syllabus * Sections * Office Hours * Web Reader
Welcome
to Metabolic Biochemistry at the Biology Department at the University of
California, San Diego for Spring Quarter 2000. This course is taught by
Dr.
Lukas Buehler.
The goal is to understand energy producing pathways (glycolysis, citric acid cycle, oxidative phosphorylation, photosynthesis, and fatty acid oxidation) and biosynthetic pathways (gluconeogenesis, glycogen synthesis, fatty acid synthesis, and amino acid and nucleic acid metabolism) including the metabolism of signaling molecules like neurotransmitters and steroid hormones. The course pays particular attention to human physiology, and the structural organization of pathways is discussed in terms of cellular location and compartmentalization, as well as coordination of pathways among different organs (metabolic integration). The importance of biological membranes for metabolic integration and regulation is addressed through discussions of transport systems for small metabolites as well as the central role of membrane biogenetic pathways in human lipid metabolism.
Updates
and exam keys
Biology Student Affairs will distribute final exams for several days following the end of the quarter, and again the first full week of the subsequent quarter. For Spring 2000 exams, the distribution dates will be:
June 20-23, from 8:30-12:00 and 1:00-4:00
September 25-29, from 8:30-12:00 and 1:00-4:00
Figure of mitochondrial carriers
ERRATA (to make important changes
in the current version)
updated 5/5/00 see comment
for p.59
Study guide for 1. midterm
with answers
Study guide for 2. midterm
(with link to answers)
Study guide for Final Exam
Ribonulceotide
Reductase Regulation
Key and regrading procedure
for 1. midterm
Key and regading procedure
for 2. midterm
Textbooksrecommended
:
(choose one)
"Biochemistry", by Voet and Voet, 2nd ed., 1995
"Fundamentals in Biochemistry" Voet, Voet and Pratt, 1998
"Biochemistry", by L. Stryer, 4th ed., 1995
...more information on textbooks..
Course
requirements and Grade:
1. Midterm: 30% (April 25; during class)
2. Midterm: 30% (May 16; during class)
Final Exam: 40% (June 12, 11:30am-2:30pm)
Teaching
Assistants
| Laura Anne Hardaker | lhardake@ucsd.edu |
| David Chen | bibc102ta@yahoo.com |
| Anthony Kempf | akempf@ucsd.edu |
| Elliot Azizollahi | eazizoll@ucsd.edu |
| Lorra Sharp | lorrasharp@hotmail.com |
| Igor Neyman | ineyman92@hotmail.com |
| Janet Moritsugu | jmoritsu@ucsd.edu |
| Valeria Pagnon | vpagnon@ucsd.edu |
| Beatriz Batarse | beatrixs@hotmail.com |
| Kathryn Gabot | jgabot@prodigy.net |
| T.J. Tzao | ttzao@ucsd.edu |
Internet
Special attention will be given to pathway comparison
among different species. This aspect of the course will be based on Internet
databases and specifically the metabolic pathway database (KEGG)
at the Japanese Genomenet WWW Server.
A Internet based lecture
supplement can be accessed here (web reader).
| Bioinformatics
Basics
by H.Rashidi and L.Buehler gives you instructions on using the Internet to retrieve information about metabolic pathways, protein structures, the human genome project, molecular evolution, and hereditary diseases. |
 |
