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Hadwiger, J.A. and R.A. Firtel (1992).  Analysis of G-alpha-4, a G protein subunit required for multicellular development in Dictyostelium. Genes Devel. 6:38-49.

Esch, R.K., P.K. Howard and R.A. Firtel (1992).  Regulation of the Dictyostelium cAMP-induced, prestalk-specific DdrasD gene: identification of cis-acting elements.  Nucl. Acids Res. 20:1325-1332.

Cubitt, A.B. and R.A. Firtel (1992).  Characterization of phospholipase activity in Dictyostelium discoideum. Identification of a Ca2+-dependent phosphoinositidase-specific phospholipase C.  Biochem. J. 283:371-378.

Powell, J.A., J. Galindo and R.A. Firtel (1992).  A negative transcriptional control region of a developmentally-regulated gene co-localizes with the origin of replication of an endogenous plasmid in Dictyostelium.  Nucl. Acids Res. 20:2795-2802.

Ceccarelli, A., H.J. Mahbubani, R. Insall, G. Schnitzler, R.A. Firtel and J.G. Williams (1992).  A G-rich sequence element common to Dictyostelium genes which differ radically in their patterns of expression.  Devel. Biol. 152:188-193.

Okaichi, K., A.B. Cubitt, G. Pitt and R.A. Firtel (1992).  Amino acid substitutions in the Dictyostelium G-alpha subunit G-alpha-2 produce dominant negative phenotypes and inhibit the activation of adenylyl cyclase, guanylyl cyclase, and phospholipase C.  Mol. Biol. Cell 3:735-747.

Howard, P., B. Sefton and R.A. Firtel (1992).  Analysis of a spatially regulated phosphotyrosine phosphatase identifies tyrosine phosphorylation as a key regulatory pathway in Dictyostelium.  Cell 71:637-647.

Mann, S.K.O., W.M. Yonemoto, S.S. Taylor and R.A. Firtel (1992).  DdPK3, which plays essential roles during Dictyostelium development, encodes  the catalytic subunit of cAMP-dependent protein kinase.  Proc. Natl. Acad. Sci. USA 89:10701-10705.

Howard, P.K., B.M. Sefton and R.A. Firtel (1993).  Tyrosine phosphorylation of actin in Dictyostelium associated with cell shape changes.  Science 259:241-244. Abstract

Powell, J.A., G.R. Schnitzler, J. Hadwiger, P. Howard, R.K. Esch, A.B. Cubitt, K. Okaichi, C. Gaskins, S.K.O. Mann and R.A. Firtel (1993). Spatial and temporal regulation of Dictyostelium development through signal transduction pathways.  In: Evolutionary Conservation of Developmental Mechanisms, Wiley-Liss, Inc., pp. 159-184.

Powell-Coffman, J.A. and R.A. Firtel (1993).  Cellular dedifferentiation and spore germination in Dictyostelium may utilize similar regulatory pathways. BioEssays 15:131-133.

Kikkawa, U., S.K.O. Mann, R.A. Firtel and T. Hunter (1993).  Molecular cloning of casein kinase II alpha subunit from Dictyostelium discoideum and its expression in the life cycle.  Mol. Cell. Biol. 12:5711-5723.

Cell-permeable non-hydrolyzable cAMP derivatives as tools for analysis of signalingSchaap, P., M. Van Ments-Cohen, R.D.M. Soede, R. Brandt, R.A. Firtel, W. Dostmann, H.-G. Genieser, B. Jastorff and P.J.M. Van Haastert (1993). Pathways controlling gene regulation in Dictyostelium.  J. Biol. Chem. 268:6323-6331.

Cubitt, A.B., F. Carrel, S. Dharmawardhane, C. Gaskins, J. Hadwiger, P. Howard, S.K.O. Mann, K. Okaichi, K. Zhou and R.A. Firtel (1993).  Molecular genetic analysis of signal transduction pathways controlling multicellular development in Dictyostelium.  Cold Spring Harbor Symp. Quant. Biol. LVII:177-192.

Cubitt, A.B., S. Dharmawardhane and R.A. Firtel (1993).  Developmentally regulated changes in 1,2-diacylglycerol in Dictyostelium: Regulation by light and G proteins.  J. Biol. Chem. 268:17431-17439.

Schatzle, J., J. Bush, S. Dharmawardhane, R.A. Firtel, R.H. Gomer and J. Cardelli (1993).  Characterization of the signal transduction pathways and cis-acting DNA sequence responsible for the transcriptional induction during growth and development of the lysosomal a-mannosidase gene in Dictyostelium discoideum. J. Biol. Chem. 268:19632-19639.

Stober-Grasser, U., B. Brydolf, X. Bin, F. Grasser, R.A. Firtel and J.S. Lipsick (1993).  The myb DNA-binding domain is highly conserved in Dictyostelium discoideum.  Oncogene 7:589-596.

Esch, R.K., G. Weeks and R.A. Firtel (1993).  Regulation and function of two developmentally regulated ras genes in Dictyostelium.  In: The Ras Superfamily of GTPases (eds. J.C. Lacal and F. McCormick), FL: CRC Press, pp. 173-186.

Mann, S.K.O. and R.A. Firtel (1993).  cAMP-dependent protein kinase differentially regulates prestalk and prespore differentiation during Dictyostelium development.  Development 119:135-146.  Abstract

Carrel, F., S. Dharmawardhane, A.M. Clark, J.A. Powell-Coffman and R.A. Firtel (1994).  Spatial and temporal expression of the Dictyostelium discoideum subunit G-alpha-2: Expression of a dominant negative protein inhibits proper prestalk to stalk differentiation.  Mol. Biol. Cell 5:7-16.  Abstract

Schnitzler, G.R., W.H. Fischer and R.A. Firtel (1994). Cloning and characterization of the G-box binding factor, an essential component of the developmental switch between early and late development in Dictyostelium.  Genes Devel. 8:502-514.  Abstract

Wu, L., C. Gaskins, R. Gundersen, J.A. Hadwiger, R.L. Johnson, G.S. Pitt, R.A. Firtel and P.N. Devreotes (1994).  Signal transduction by G-proteins in Dictyostelium discoideum.  In: Handbook of Experimental Pharmacology, Vol. 108/II GTPases in Biology II (eds. B. Dickey and L. Birnbaumer), Berlin, Germany: Springer-Verlag Publication, pp. 335-349.

Dynes, J.L., A.M. Clark, G. Shaulsky, A. Kuspa, W.F. Loomis and R.A. Firtel (1994).  LagC is required for cell-cell interactions that are essential for cell-type differentiation in Dictyostelium.  Genes Devel. 8:948-958.  Abstract

Wu, L., C. Gaskins, K. Zhou, R.A. Firtel and P.N. Devreotes (1994). Cloning and targeted mutations of G-alpha-7 and G-alpha-8, two developmentally regulated G protein a-subunit genes in Dictyostelium.  Mol. Biol. Cell 5:691-702.  Abstract

Powell-Coffman J.A. and R.A. Firtel (1994). Characterization of a novel Dictyostelium discoideum prespore-specific gene, PspB, reveals conserved regulatory sequences.  Development 120:1601-1611.  Abstract

Powell-Coffman, J.A., G.R. Schnitzler and R.A. Firtel (1994).  A GBF-binding site and a novel AT element define the minimal sequences sufficient to direct prespore-specific expression in Dictyostelium.  Mol. Cell. Biol. 14:5840-5849.  Abstract

Howard, P.K., M. Gamper, T. Hunter and R.A. Firtel (1994). Regulation by protein-tyrosine phosphatase PTP2 is distinct from that by PTP1 during Dictyostelium growth and development.  Mol. Cell. Biol. 14:5154-5164.  Abstract

Gaskins, C., M. Maeda and R.A. Firtel (1994). Identification and functional analysis of a developmentally regulated extracellular signal-regulated kinase gene in Dictyostelium discoideum.  Mol. Cell. Biol. 14:6996-7012.  Abstract

Hadwiger, J.A., S. Lee and R.A. Firtel (1994).  The G-alpha subunit G-alpha-4 couples to pterin receptors and identifies a signaling pathway that is essential for multicellular development in Dictyostelium.  Proc. Natl. Acad. Sci. USA 91:10566-10570. Abstract

Mann, S.K., D.L. Richardson, S. Lee, A.R. Kimmel and R.A. Firtel (1994).  Expression of cAMP-dependent protein kinase in prespore cells is sufficient to induce spore cell differentiation in Dictyostelium.  Proc. Natl. Acad. Sci. USA 91:10561-10565. Abstract

Mann, S.K.O., P.N. Devreotes, S. Eliott, K. Jermyn, A. Kuspa, M. Fechheimer, R. Furukawa, C.A. Parent, J. Segall, G. Shaulsky, P.H. Vardy, J. Williams, K. Williams and R.A. Firtel (1994).  Cell biological, molecular genetic, and biochemical methods to examine Dictyostelium.  In: Cell Biology: A Laboratory Handbook (ed. J. Celis), Academic Press, pp. 412-451.

Hori, R. and R.A. Firtel (1994).  Identification and characterization of multiple A/T-rich cis-acting elements that control expression from the Dictyostelium actin promoters: The Dictyostelium actin upstream activating sequence confers growth-phase expression and has enhancer-like properties.  Nucl. Acids Res. 22:5099-5111.

Dharmawardhane, S., A.B. Cubitt and R.A. Firtel (1994).  Regulatory role of G-alpha-1 subunit in controlling cellular morphogenesis in Dictyostelium. Development 120:3549-3561. Abstract

Segall, J.E., A. Kuspa, G. Shaulsky, M. Ecke, M. Maeda, C. Gaskins, R.A. Firtel and W.F. Loomis (1995).  A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium.  J. Cell Biol. 128:405-413.

Cao, J.-G. and R.A. Firtel (1995). Growth and developmental functions of a human immunodeficiency virus Tat-binding protein/26S protease subunit homolog from Dictyostelium discoideum.  Mol. Cell. Biol. 15:1725-1736.

Briscoe, C. and R.A. Firtel (1995).  A kinase for cell-fate determination? GSK-3, a ubiquitous kinase regulated by tyrosine phosphorylation, controls cell-fate decisions in both Drosophila and Dictyostelium; genetic analysis of its interactions with other signaling pathways is now possible.  Curr. Biol. 5:228-231.

Gamper, M., P.K. Howard, T. Hunter and R.A. Firtel (1995).  Protein tyrosine phosphatases in Dictyostelium discoideum.  Adv. Prot. Phosphatases 9:25-49.

Schnitzler, G.R., C. Briscoe, J.M. Brown and R.A. Firtel (1995).  Serpentine cAMP receptors may act though a G protein-independent pathway to induce postaggregative development in Dictyostelium.  Cell 81:737-745.  Abstract

Firtel, R.A. (1995).  Integration of signaling information in controlling cell-fate decisions in Dictyostelium.  Genes Devel. 9:1427-1444.

Cubitt, A.B., R.A. Firtel, G. Fischer, L.F. Jaffe and A.L. Miller (1995).  Patterns of free calcium in multicellular stages of Dictyostelium expressing jellyfish apoaequorin. Development 121:2291-2301.  Full Text,  Abstract

Gaskins, C., A.M. Clark, L. Aubry, J.E. Segall and R.A. Firtel (1996).  The Dictyostelium MAP kinase ERK2 regulates multiple, independent developmental  pathways. Genes Devel. 10:118-128.  Abstract

Maeda, M., L. Aubry, R. Insall, C. Gaskins, P. Devreotes and R. Firtel (1996).  Seven helix chemoattractant receptors transiently stimulate mitogen-activated protein kinase in Dictyostelium.  J. Biol. Chem. 271:3351-3354.  Full Text,  Abstract

Gamper, M., P.K. Howard and R.A. Firtel (1996).  Multiple roles of the novel protein tyrosine phosphatase PTP3 during Dictyostelium growth and development.  Mol. Cell. Biol. 16:2431-2444.  Abstract

Zhou, K., K. Takegawa, S.D. Emr and R.A. Firtel (1996).  A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: Biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development.  Mol. Cell. Biol. 15:5645-5656.  Abstract

Hadwiger, J.A., K. Natarajan and R.A. Firtel (1996).  Mutations in the Dictyostelium heterotrimeric G protein alphasubunit G-alpha-5 alter the kinetics of tip morphogenesis.  Development 122:1215-1224.  Full text,  Abstract

Firtel, R.A. (1996).  Interacting signaling pathways controlling multicellular development in Dictyostelium.  Curr. Opin. Genet. Devel. 6:545-554.

Aubry, L., M. Maeda, R. Insall, P.N. Devreotes and R.A. Firtel (1997).  The Dictyostelium mitogen-activated protein kinase ERK2 is regulated by Ras and cAMP-dependent protein kinase (PKA) and mediates PKA function.  J. Biol. Chem. (Communication) 272:3883-3886. Full text,  Abstract

Mann, S.K.O., P.N. Devreotes, S. Eliott, K. Jermyn, A. Kuspa, M. Fechheimer, R. Furukawa, C.A. Parent, J. Segall, G. Shaulsky, P.H. Vardy, J. Williams, K.L. Williams and R.A. Firtel (1998).  Cell biological, molecular genetic, and biochemical methods used to examine Dictyostelium.  In: Cell Biology: A Laboratory Handbook, Second Edition, Volume 1 (ed. J. Celis), Academic Press, pp. 431-465.

Mann, S.K.O., J.M. Brown, C. Briscoe, C. Parent, G. Pitt, P.N. Devreotes and R.A. Firtel (1997).  Role of cAMP-dependent protein kinase in controlling aggregation and post-aggregative development in Dictyostelium.  Devel. Biol. 183:208-221.  Full text,  Abstract

Lee, S., R. Escalante and R.A. Firtel (1997).  A Ras GAP is essential for cytokinesis and spatial patterning in Dictyostelium.  Development 124:983-996.  Full text,  Abstract

Ma, H., M. Gamper, C. Parent and R.A. Firtel (1997).  The Dictyostelium MAP kinase kinase DdMEK1 regulates chemotaxis and is essential for chemoattractant-mediated activation of guanylyl cyclase.  EMBO J. 16:4317-4332.  Full text,  Abstract

Buczynski, G, B. Grove, A. Nomura, M. Kleve, J. Bush, R.A. Firtel and J. Cardelli (1997).  Inactivation of two Dictyostelium discoideum genes, DdPIK1 and DdPIK2, encoding proteins related to mammalian phosphatidylinositide 3-kinases, results in defects in endocytosis, lysosome to postlysosome transport, and actin cytoskeleton organization.  J. Cell Biol. 136:1271-1286.  Full text

Maeda, M. and R.A. Firtel (1997).  Activation of the mitogen-activated protein kinase ERK2 by the chemoattractant folic acid in Dictyostelium.  J. Biol. Chem. 272:3690-23695.  Full text,  Abstract

Clark, A., A. Nomura , S. Mohanty and R.A. Firtel (1997).  A ubiquitin-conjugating enzyme is essential for developmental transitions in Dictyostelium.  Mol. Biol. Cell 8:1989-2002.  Full text,  Abstract

Brown, J.M., C. Briscoe and R.A. Firtel (1997).  Control of transcriptional regulation by signal transduction pathways in Dictyostelium during multicellular development.  In: Dictyostelium--A Model System for Cell and Developmental Biology (eds Y. Maeda, K. Inouye and I. Takeuchi), Universial Academy Press, Inc., Tokyo, pp. 245-265.

Rietdorf, J., F. Siegert, S. Dharmawardhane, R.A. Firtel and C.J. Weijer (1997).  Analysis of cell movement and signalling during ring formation in an activated Ga1 mutant of Dictyostelium discoideum that is defective in prestalk zone formation.  Devel. Biol. 181:79-90.  Full text

Han, Z. and R.A. Firtel (1998).  The homeobox-containing gene Wariai regulates anterior-posterior patterning and cell-type homeostasis in Dictyostelium. Development 125:313-325. Full text,  Abstract

Cubitt, A.B., I. Reddy, S. Lee, J.G. McNally and R.A. Firtel (1998).  Coexpression of a constitutively active plasma membrane calcium pump with GFP identifies roles for intracellular calcium in controlling cell sorting during morphogenesis in Dictyostelium.  Devel. Biol. 196:77-94.  Abstract

Aubry, L. and R.A. Firtel (1998).  Spalten, a protein containing G-alpha-protein-like and PP2C domains, is essential for cell-type differentiation in Dictyostelium.  Genes Devel. 12:1525-1538.  Full text,  Abstract

Yasukawa, H., S. Mohanty and R.A. Firtel (1998).  Identification and analysis of a gene that is essential for morphogenesis and prespore cell differentiation in Dictyostelium.  Development 125:2565-2576.  Full text,  Abstract

Sukumaran, S., J.M. Brown, R.A. Firtel and J.G. McNally (1998).  lagC-null and gbf-null cells define key steps in the morphogenesis of Dictyostelium mounds. Devel. Biol. 200:16-26. Full text

Araki, T., M. Gamper, A. Early, M. Fukuzawa, T. Abe, E. Kim, R.A. Firtel and J.G. Williams (1998).  Developmentally and spatially regulated activation of a Dictyostelium STAT protein by a serpentine receptor.  EMBO J. 17:4018-4028.  Full text,  Abstract

Brown, J.M. and R.A. Firtel (1998)  Phosphorelay signaling: New tricks for an ancient pathway.  Curr. Biol. 8: R662-R665.

Chung, C., T.B.K. Reddy, K. Zhou and R.A. Firtel (1998).  A novel, putative MEK kinase controls developmental timing and spatial patterning in Dictyostelium and is regulated by ubiquitin-mediated protein degradation.  Genes Devel.12:3564-3578.  Full text,  Abstract

Gamper, M., E. Kim, P.K. Howard, H. Ma, T. Hunter and R. A. Firtel (1999).  Regulation of Dictyostelium protein-tyrosine phosphatase-3 (PTP3) through osmotic shock and stress stimulation and identification of pp130 as a PTP3 substrate.  J. Biol. Chem.274:12129-12138.  Full text,  Abstract

Meili, R., C. Ellsworth, S. Lee, T.B.K. Reddy, H. Ma and R.A. Firtel (1999).  Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium.  EMBO J. 18:2092-2105.  Full text,  Abstract

Mohanty, S., K.A. Jermyn, A. Early, T. Kawata, L. Aubry, A. Ceccarelli, P. Schaap, J.G. Williams and R.A. Firtel (1999).  Evidence that the Dictyostelium Dd-STATa protein is a repressor that regulates commitment to stalk cell differentiation and is also required for chemotaxis.  Development 126:3391-3405.  Full text,  Abstract

Lee, S., C.A. Parent, R. Insall and R.A. Firtel (1999).  A novel Ras interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium.  Mol. Biol. Cell 10:2829-2845.  Full text,  Abstract

Chung, C.Y. and R.A. Firtel (1999).  PAKa, a putative PAK family member, is required for cytokinesis and the regulation of the cytoskeleton in Dictyostelium discoideum cells during chemotaxis.  J. Cell Biol. 147:559-575.  Full text,  Abstract

Aubry, L. and R.A. Firtel (1999).  Integration of signaling networks that regulate Dictyostelium differentiation.  Ann. Rev. Cell Devel. Biol. 15:469-517. Full text,  Abstract

Chung, C.Y. and R.A. Firtel (2000).  Dictyostelium: A model experimental system for elucidating the pathways and mechanisms controlling chemotaxis.  In: Principles of Molecular Regulation (eds. P.M. Conn and A. Means), Totowa, NJ: The Humana Press, pp. 99-114. Full text, Abstract

Brown, J.M. and R.A. Firtel (2000).  Regulation of cell-fate determination in Dictyostelium.  Devel. Biol. 216:426-441. Full text,  Abstract

Mohanty, S. and R.A. Firtel (2000).  Control of spatial patterning and cell-type proportioning in Dictyostelium.  Sem. Cell Devel. Biol. 10:597-607.  Full text,  Abstract

Chien, S., C. Chung, S. Sukumaran, N. Osborne, S. Lee, C. Ellsworth, J.G. McNally and R.A. Firtel (2000).  The Dictyostelium LIM domain-containing protein LIM2 is essential for proper chemotaxis and morphogenesis.  Mol. Biol. Cell 11:1275-1291.  Full text,  Abstract

Chung, C., S. Lee, C. Briscoe, C. Ellsworth and R.A. Firtel (2000).  Role of Rac in controlling the actin cytoskeleton and chemotaxis in motile cells.  Proc. Natl. Acad. Sci. USA. 97:5225-5230. Full text, Abstract

Brown, J.M. and R.A. Firtel (2000).  Just the right size: Cell counting in Dictyostelium.  Trends Genet. 16:191-193.  Full text,  Abstract

Firtel, R.A. and C.Y. Chung (2000).  The molecular genetics of chemotaxis: Sensing and responding to chemoattractant gradients.  BioEssays 22:603-615.  Full text,  Abstract

Firtel, R.A. and R. Meili (2000).  Dictyostelium: A model for regulated cell movement during morphogenesis.  Curr. Opin. Genet. Devel. 10:421-427. Full text,Abstract

Firtel, R.A. and D. Ish-Horowicz (2000).  Differentiation and gene regulation: A rich developmental stew.  Curr. Opin. Genet. Devel. 10:469-470.

Nelson, M.K., A. Clark, T. Abe, A. Nomura, N. Yadava, C.J. Funair, K.A. Jermyn, S. Mohanty, R.A. Firtel and J.G. Williams (2000).  An F-box/WD40 repeat-containing protein important for Dictyostelium cell-type proportioning, slug behavior and culmination.  Devel. Biol. 224:42-59.  Full text, Abstract

Meili, R., C. Ellsworth and R.A. Firtel (2000).  A novel Akt/PKB-related kinase is essential for morphogenesis in Dictyostelium.  Curr. Biol. 10:708-717.  Full text,  Abstract

Williams, J.G. and  R.A. Firtel  (2000).  HAPPY days for the Dictyostelium genome project.  Genome Res. 10:1658-1659.

Wang, J., L. Hou, D. Awrey, W.F. Loomis, R.A. Firtel and C. Siu (2000).  The membrane glycoprotein gp150 is encoded by the lagC gene and mediates cell-cell adhesion by heterophilic binding during Dictyostelium development.  Devel. Biol. 227:734-745.  Abstract

Early, A., M. Gamper, J. Moniakis, E. Kim, T. Hunter, J.G. Williams and R.A. Firtel (2001).  Protein tyrosine phosphatase PTP1 negatively regulates Dictyostelium STATa and is required for proper cell-type proportioning.  Devel. Biol. 232:233-245. Full text, Abstract

Moniakis, J., S. Funamoto, M. Fukuzawa, J. Meisenhelder, T. Araki, T. Abe, R. Meili, T. Hunter, J. Williams and R.A. Firtel (2001).  An SH2-domain-containing kinase negatively regulates the phosphatidylinositol-3 kinase pathway.  Genes Devel. 15:687-698. Full text, Abstract

Briscoe, C., J. Moniakis, J.Y. Kim, J.M. Brown, D. Hereld, P.N. Devreotes and R.A. Firtel (2001).  The phosphorylated C-terminus of cAR1 plays a role in cell-type-specific gene expression and STATa tyrosine phosphorylation.  Devel. Biol. 223:225-236. Full text,  Abstract

Chung, C.Y., G. Potikyan and R.A. Firtel (2001).  Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa.  Mol. Cell 7:937-947. Full text,  Abstract

Brown, J.M. and R.A. Firtel (2001).  Functional and regulatory analysis of the Dictyostelium G-box binding factor.  Devel. Biol. 234:521-534. Full text,  Abstract

Funamoto, S., K. Milan, R. Meili and R.A. Firtel (2001).  Role of phosphatidylinositol 3' kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in Dictyostelium.  J. Cell Biol. 153:705-809. Full text,  Abstract

Mohanty, S., S. Lee, N. Yadava, M.J. Dealy, R.S. Johnson and R.A. Firtel (2001).  Regulated protein degradation controls PKA function and cell-type differentiation in Dictyostelium.  Genes Devel. 15:1435-1448. Full text,  Abstract

Chung, C.Y., S. Funamoto and R.A. Firtel (2001).  Signaling pathways controlling cell polarity and chemotaxis.  Trends Biochem. Sci. 26:557-566 Full text,  Abstract, Supplementary information

Sobko, A., H. Ma, and R A. Firtel (2002).    Regulated SUMOylation and ubiquitination of DdMEK1 is required for proper chemotaxis. Devel. Cell 2:745-756.  Full text,  Abstract

Funamoto, S., R. Meili, S. Lee, L. Parry and R.A. Firtel (2002).  Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis.  Cell 109:611-623.  Full text,  Abstract

Han, Y-H., C.Y. Chung, S. Stephens, D. Wessels, M.A. Titus, D.R. Soll and R.A. Firtel (2002).  Requirement of a vasodilator-stimulated phosphoprotein (VASP) family member for cell adhesion, the formation of filopodia, and chemotaxis in Dictyostelium. J. Biol. Chem. 277:49877-49887.  Full text,  Abstract

Meili, R and R.A. Firtel (2002). Leading the way.  Nature Cell Biol. 4:E171.  Full text, Abstract

Sun, B. and R.A. Firtel (2003).  A regulator of G protein signaling-containing kinase is important for chemotaxis and multicellular development in Dictyostelium.  Mol. Biol. Cell 14:1727-1743.   Full text, Abstract

Meili, R and R.A. Firtel (2003). Follow the leader. Devel. Cell Biol. 4:291-293.  Full text, Abstract

Chung, C.Y. and R.A Firtel (2003). Signaling pathways at the leading edge of chemotaxing cells. J. Muscle Res. Cell Motility (Special DictyosteliumIssue) 23:773-779. Full text, Abstract

Meili, R and R.A. Firtel (2003). Two poles and a compass. Cell 114:153-156. Full text, Abstract

Merlot, S. and R.A. Firtel (2003). Leading the way: Directional sensing through phosphatidylinositol 3-kinase and other signaling pathways. J. Cell Sci. 116:3471-3478. Full text, Abstract

Firtel, R.A. and R. Meili (2003). The role of PI3 kinase in directional sensing during chemotaxis in Dictyostelium, a model for chemotaxis in neutrophils and macrophages. In: Handbook of Cell Signaling, Vol. 2 (eds. R. Bradshaw and E. Dennis), San Diego: Academic Press, pp. 217-223.

Sun, B., H. Ma and R.A. Firtel (2003). Dictyostelium stress-activated protein kinase a, a novel stress-activated mitogen-activated protein kinase kinase kinase-like kinase, is important for the proper regulation of the cytoskeleton. Mol. Biol. Cell 14:4526-4540. Full text, Abstract

Merlot, S., R. Meili, D. Pagliarini, T. Maehama, J.E. Dixon and R.A. Firtel (2003). A PTEN-related 5’-phosphatidylinositol phosphatase localized in the Golgi. J. Biol. Chem. 278:39866-39873. Full text, Abstract

Aubry, L., S. Lee, K. Ravanel and R.A. Firtel (2003). The novel ankyrin-repeat containing kinase ARCK-1 acts as a suppressor of the Spalten signaling pathway during Dictyostelium development. Devel. Biol. 263:308-322. Full text, Abstract

Ridley, A.J., M.A. Schwartz, K. Burridge, R.A. Firtel, M.H. Ginsberg, G. Borisy, J.T. Parsons and A.R. Horwitz (2003). Cell migration: Integrating signals from front to back. Science 302:1704-1709. Full text, Abstract

Chisholm, R.L. and R.A. Firtel (2004). Insights into morphogenesis from a simple developmental system. Nature Rev. Mol. Cell Biol. 5:531-541. Full text, Abstract

Sasaki, A.T., C. Chun, K. Takeda and R.A. Firtel (2004). Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement.  J. Cell Biol. 167:505-518. Full text, Abstract

Park, K.C., F. Rivero, R. Meili, S. Lee, F. Apone and R.A. Firtel (2004). Rac regulation of chemotaxis and morphogenesis in Dictyostelium. EMBO J. 23:4177-4189. Full text, Abstract

Charest, P.G. and R.A. Firtel (2006).  Feedback signaling controls leading-edge formation during chemotaxis.  Curr. Opin. Genet. Devel. 16:339-347.  Full text, Abstract

Mendoza, M.C. and R.A. Firtel (2006).  Assaying chemotaixs of Dictyostelium cells.  In: Methods in Molecular Biology, Vol. 346: Dictyostelium discoideum Protocols, (eds. L. Eichinger and F. Rivero), New Jersey: Humana Press, pp. 393-405.  Full text, Abstract

Sasaki, A.T. and R.A. Firtel (2006).  Regulation of chemotaxis by the orchestrated activation of Ras, PI3K, and TOR.  Eur. J. Cell Biol. 85:873-895.  Full text, Abstract

Charest, P. and R.A. Firtel (2007).  Big roles for small GTPases in the control of directed cell movement.  Biochem. J. 401:377-390.  Full text, Abstract

Jeon, T.J., D. Lee, S. Merlot, N. Nguyen, G. Weeks and R.A. Firtel (2007).  Rap1 controls cell adhesion and cell motility through the regulation of myosin II.  J. Cell Biol. 176:1021-1033.  Full text, Abstract

 Mendoza, M.C., E.O. Booth, G. Shaulsky and R.A. Firtel (2007).  MEK1 and protein phosphatase 4 coordinate Dictyostelium development and chemotaxis.  Mol. Cell. Biol. 27:3817-3827.  Full text, Abstract

Takeda, K., A.T. Sasaki , H. Ha, H. Seung and R.A. Firtel (2007).  Role of phosphatidylinositol 3-kinases in chemotaxis in Dictyostelium.  J. Biol. Chem. 282:11874-11884.  Full text, Abstract

Sasaki, A., C. Janetopoulos, S. Lee, P.G. Charest, K. Takeda, L.W. Sundheimer, R. Meili, P.N. Devreotes and R.A. Firtel (2007).  G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility.  J. Cell Biol. 178:185-191.  Full text, Abstract

Del Alamo, J.C., R. Meili, B. Alonso-Latorre, J. Rodriguez-Rodriguez, A. Aliseda, R.A. Firtel and J.C. Lasheras (2007).  Spatio-temporal analysis of eucaryotic cell motility by improved force cytometry.  Proc. Natl. Acad. Sci. USA 104:13343-13348.  Full text, Abstract

Kolsch, V., P.G. Charest and R.A. Firtel (2008)  The regulation of cell motility and chemotaxis by phospholipid signaling.  J. Cell Sci. 121:551-559. (Invited Review)

Janetopoulos, C. and R.A. Firtel (2008).  Directional sensing during chemotaxis.  FEBS Lett. 582:2075-2085. (Invited Review Issue)

Araki, T., J. Langenick, M. Gamper, R.A. Firtel and J.G. Williams (2008).  Evidence that DIF-1 and hyper-osmitic stress activate a Dictyostelium STAT by inhibiting a specific protein tyrosine phosphatase.
Development 135:1347-1353.

Jeon, T.J., D. Lee, S. Lee, G. Weeks and R.A. Firtel (2007).  Regulation of Rap1 activity by RapGAP1 controls cell adhesion at the front of chemotaxing cells.  J. Cell Biol. 179:833-843.

Du, F., K. Edwards, Z. Shen, B. Sun, A. De Lozanne, S. Briggs and R.A. Firtel (2008).  Regulation of contractile vacuole formation and activity in Dictyostelium.  EMBO J., in press.

Zhang, S, P.G. Charest and R.A. Firtel (2008). Spatio-temporal regulation of Ras activity provides directional sensing. Curr. Biol., in press.

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